Page 47 - Migraine, the heart and the brain

eTable 3. Mean Z-scores of cognitive performance in different domains by deep white matter hyperintensity load (DWMH)
Structural Brain Changes in Migraine
non-high DWMH
N Mean (SD)
219 0.0 (2.7) 219 0.0 (1.0) 216 0.0 (2.6) 219 0.1 (1.0) 187 0.2 (3.6) 216 0.1 (1.6)
223 0.2 (2.6) 223 0.1 (1.0) 223 0.1 (2.8) 222 0.1 (1.0) 219 0.4 (4.3) 223 0.3 (1.7) 166 0.1 (1.0)
184 0.3 (8.9) 218 1.4 (9.2)
high DWMH
P [95% CI] (model 1)
0.5 [-0.5 to 1.0] 0.8 [-0.2 to 0.3] 0.4 [-1.0 to 0.4] 0.3 [-0.4 to 0.1] 0.4 [-1.7 to 0.6] 0.6 [-0.5 to 0.3]
0.2 [-1.2 to 0.3] 0.06 [-0.6 to 0.0] 0.7 [-0.6 to 0.9] 0.1 [-0.5 to 0.0] 0.09 [-2.1 to 0.2] 0.3 [-0.2 to 0.7] 0.4 [-0.5 to 0.2]
0.8 [-2.9 to 2.3] 0.07 [-4.5 to 0.2]
P [95% CI] 2 (model 2)
0.5 [-0.5 to 1.0] 0.8 [-0.2 to 0.3] 0.4 [-1.0 to 0.4] 0.3 [-0.4 to 0.1] 0.4 [-1.7 to 0.6] 0.6 [-0.5 to 0.3]
0.2 [-1.2 to 0.3] 0.06 [-0.6 to 0.0] 0.8 [-0.6 to 0.9] 0.1 [-0.5 to 0.0] 0.09 [-2.1 to 0.2] 0.3 [-0.2 to 0.7] 0.4 [-0.5 to 0.2]
0.8 [-2.9 to 2.3] 0.07 [-4.5 to 0.2]
Cognitive function at baseline
Memory: immediate recall
Memory: delayed recall
Concentration, attention
Processing speed
Visuo-spatial, motor skills
Executive function
Cognitive function at follow- up
Memory: immediate recall Memory: delayed recall Concentration, attention Processing speed Visuo-spatial, motor skills Executive function
Fluid intelligence
Overall cognitive performance
CAMERA-1 (baseline) CAMERA-2 (follow-up)
N
57 57 57 57 50 57
53 53 51 53 53 51 30
50 51
Mean (SD)
-0.0 (2.5) -0.1 (0.9) -0.2 (2.5) -0.3 (1.0) -0.8 (2.9) -0.3 (1.5)
-0.7 (2.7) -0.3 (1.0) -0.6 (2.4) -0.4 (0.9) -1.7 (4.0) -0.1 (1.7) -0.2 (1.0)
-1.8 (8.2) -3.7 (8.9)
Legends:
High DWMH de ned as the upper quintile of DWMH distribution.
Model 1: Adjusted for age, gender, level of education; Model 2: Adjusted for age, gender, level of education, and migraine diagnosis
Z-scores indicate by how many standard deviations an observation is above or below the mean. Higher score indicates better cognitive performance
Comment
We prospectively evaluated associations of migraine with structure and function of the brain at the 9-year follow-up. Among men, we found no association of migraine with progression of MRI-measured brain lesions. Women in the migraine group had a higher prevalence and a greater increase of deep white matter hyperintensities than women in the control group. Although migraine was associated with a higher prevalence of infratentorial hyperintensities at follow up, there were no signi cant associations of migraine with progression of infratentorial hyperintensities or
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