Page 56 - Functional impairment and cues for rehabilitation of head and neck cancer patients -

Chapter 2
Appendix 11 Self-reported swallowing outcomes and secondary functional outcomes at 12-month follow-up of participants who were offered surgery and RT only grouped by HPV status. Adjusted Poisson regression analysis
(adjusted for age, gender, ACE-27, smoking status, tumour site, TNM-stage, problems) comparing RT to surgery (reference).
HPV-status and pre-treatment swallowing
HPV negative
Number of participants (%)
HPV positive
Regression analysis
Number of participants (%)
Regression analysis
Surgery (n = 55)
Self-reported swallowing outcomes (from EORTC-QLQ-H&N35)
12-month follow-up
RT
(n = 59)
Adjusted RR (95% CI)
P
value
Surgery (n = 69)
RT
(n = 66)
Adjusted RR (95% CI)
P
value
Problems No
15 (60) 10 (40) 34
23 (89) 3 (12) 33
23 (92) 2 (8) 34
16 (62) 10 (39) 33
12 (50) 12 (50) 35
23 (92) 2 (8) 34
18 (69) 8 (31) 33
23 (92) 2 (8) 34
20 (80) 5 (20)
34
3 (12) 23 (89) 33
1.5
2.1
2.7
1.5
2.1
NA
1.1
0.8
1.7
4.5
(0.6–3.7)
(0.3–13.6)
(0.5–13.4)
(0.6–3.5)
(0.9–4.9)
(0.3–4.0)
(0.2–4.2)
(0.4–6.7)
(1.9–10.6)
.344
.405
.229
.401
.074
.850
.781
.460
.001
31 (76) 10 (24) 28
38 (93) 3 (7) 28
39 (95) 2 (5) 28
32 (78) 9 (22) 28
36 (88) 5 (12) 28
39 (95) 2 (5) 28
32 (82) 7 (18) 30
40 (98) 1 (2) 28
33 (81) 8 (20)
28
17 (42) 24 (59) 28
29 (67) 14 (33) 23
40 (93) 3 (7) 23
38 (88) 5 (12) 23
29 (67) 14 (33) 23
30 (71) 12 (29) 24
1.3 (0.6–2.8) .490
0.4 (0.1–3.2) .421
2.1 (0.4–10.3) .374
1.3 (0.6–2.8) .490
1.4 (0.5–4.2) .509
swallowing
liquids,
pureed or Unknown solid food
swallowing liquids
Unknown 18
swallowing pureed food
Unknown 18
swallowing solid food
Unknown 18
Tube feeding No
Yes 1 (3)
28 (76) Yes 9 (24)
18
Problems No
Problems No
36 (97) Yes 1 (3)
Problems No
36 (97) Yes 1 (3)
28 (76) Yes 9 (24)
Weight loss No
Yes 8 (23)
Pain mouth, No jaw or throat Yes
25 (71)
34 (81) 8 (19) 24
35 (81) 8 (19) 23
38 (88) 5 (12)
23
10 (23) 33 (77) 23
2.3 (0.6–8.5) .198
8.5 (3.2–23.0) <.001
0.6 (0.2–2.2) .420
1.2 (0.8–1.9) .327
27 (77) Unknown 20
36 (97) Unknown 18
43 (100) NA 0 (0)
23
10 (29) Unknown 20
Coughing No
Yes 3 (8)
34 (92) Unknown 18
54
Secondary functional outcomes (from EORTC-QLQ-H&N35)
12-month follow-up
Trouble No
opening mouth
33 (89) Yes 4 (11)
Unknown 18
Dry mouth No
Yes 11 (30)
26 (70) Unknown 18