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Chapter 2
In both the HPV-negative and -positive participants, those who were offered RT reported more swallowing problems at 12-month follow-up (see Figure 4 and Appendix 11). However, differences were smaller within the HPV-positive group, probably due to a higher proportion of participants who received adjuvant treatment after surgery.
HPV-negative participants who were offered RT had a potentially worse survival than those who were offered surgery (HR 2.5; 95% CI 0.8–7.5, p = .100). There was no evidence of a difference in survival in HPV-positive participants offered surgery compared to those offered RT (HR 0.7; 95% CI 0.2–3.4, p = .683) (Appendix 12).
Figure 3 Kaplan Meier Curves. Left: Survival by intended treatment (p = .219). Right: Survival by received treatment (p = .189).
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