Page 158 - Physico-Chemical Niche Conditions for Bone Cells

RGD-functionalized supported lipid bilayers modulate pre-osteoblasts
CONCLUSIONS
This study realized for the first time pre-osteoblast adhesion and enhanced differentiation on RGD-functionalized SLBs, which could point to a new horizon in the management of bone regeneration using biomaterials. These results, together with the possibility to adjust SLB fluidity and to incorporate additional proteins that can optimize cellular function, for example, growth factors, cytokines and/or antibacterial agents, as well as SLBs non-fouling nature make SLBs highly promising as substrate to develop innovative biomimetic coatings for biomaterials in bone regeneration.
ACKNOWLEDGMENTS
The authors acknowledge Dr. M.L. Verheijden for help with peptide synthesis and purification. The work of J. Jin was granted by the China Scholarship Council (CSC, No. 201608530156). M. Haroon was funded by the European Commission through MOVE-AGE, an Erasmus Mundus Joint Doctorate programme (Grant number: 2014-0691).
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