Page 27 - 89Zr-Immuno-PET:Towards a Clinical Tool to Guide Antibody-based Therapy in Cancer
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Patient Sex
1 F
2 M
3 F
4 F
5 M
6 F
7 M
8 M
9 F
10 F
11 M
12 M
13 F
14 M
15 M
16 F
17 M
19 M
20 M
Age Weight (kg)
57 68 57 82 72 71 53 81 63 78 58 62 54 67 55 72 54 82 65 67 53 90 59 75 49 49
58 100 48 115 63 67 53 104 71 87 60 58
Primary tumor
Oral cavity, tongue, right
Oropharynx, base of tongue, right
Oropharynx, tonsil, right
Oropharynx, tonsil, right
Oropharynx, tonsil, right
Oral cavity, floor of mouth, left
Oral cavity, tongue, right
Oropharynx, tonsil, left
Hypopharynx, piriform sinus, left
Oral cavity, base of tongue, right
Larynx, glottic
Larynx, supraglottic
Residual disease of T2N0 tonsil carcinoma, left
Oropharynx, base of tongue, right Oropharynx, tonsil, right Oropharynx, tonsil, left Oropharynx, tonsil, right Oropharynx, soft palate, right Larynx, supraglottic, recurrence
cTNM pTNM
T2N0M0 T2N1M0 TXN2aM0 T1N2bM0 T2N2bM0 T2N2bM0 T3N0M0 T3N2bM0 T4N0M0 T4N2bM0 T4N0M0 T4N2bM0 T3N0M0 T3N2bM0 T4N2aM0 T4N2bM0 T4N2bM0 T4N2bM0 T2N0M0 T2N0M0 T4N0M0 T4N0M0 T4N0M0 T4N0M0 NA NA
T2N2bM0 T2N2bM0 T3N0M0 T3N1M0 T3N2bM0 T3N2cM0 T2N3M0 T2N3M0 T3N2cM0 T2N2cM0 NA NA
Dosimetry of immuno-PET with 89Zr-cmAb U36
3 h post-injection (p.i.). On the basis of previous studies with anti-CD44v6 mAbs,
cmAb U36 included, no adverse effects had to be expected (17). Dose rates (μSv/h)
were measured at 1, 24, and 72 h p.i. at a distance of 100 cm with a γ-radiation dose
rate counter (Berthold LB 1230 EG&G, Wildbad, Germany). In addition, human 2 anti-cmAb U36 and anti-Df-cmAb U36 antibody responses were assessed (2).
Table 1. Patient and tumor characteristics
Abbreviations: NA, not applicable
Monoclonal antibody U36
Selection and production of mouse mAb (mmAb) U36 and its chimeric IgG1 derivative cmAb U36 have been described previously (17). mAb U36 binds to the v6 region of CD44 (CD44v6). Expression of CD44v6 was found to be abundant and homogenous in 96% of all primary HNSCC and HNSCC lymph node metastases (18). In normal tissues, expression has been found in epithelial tissues such as skin, breast and prostate myoepithelium, and bronchial epithelium (19). CD44v6 has been suggested to be involved in tumor formation, tumor cell invasion, metastasis formation, and cancer cell stemness (20,21).
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