Page 118 - 89Zr-Immuno-PET:Towards a Clinical Tool to Guide Antibody-based Therapy in Cancer

Chapter 5
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Supplemental Table 2 Normal tissue and tumor uptake of Zr-89-mAbs
VOI type
89Zr-antiCD20 89Zr-antiEGFR
89Zr-antiCD44
Brain Kidney Lung Spleen Liver Combined
0.6 0.5 0.5 (0.5-0.7) (0.4-0.6) (0.4-0.6)
0.7 0.5 0.5 0.7 0.5 (0.7-0.9) (0.4-0.6) (0.4-0.5) (0.6-1.0) (0.3-0.6)
0.5 0.7 0.6 0.4 (0.4-0.7) (0.6-0.7) (0.4-0.7) (0.4-0.5)
Blood pool Bone marrow
11.5 5.9 4.2 (10.5-12.6) (4.9-6.4) (2.9-4.7)
11.2 5.9 3.9 9.5 4.7 (10.8-12.7) (5.0-6.3) (2.9-5.5) (7.8-13.1) (2.3-6.3)
4.0 9.1 5.8 3.0 (1.9-4.7) (7.4-11.2) (4.3-7.0) (1.9-3.9)
Tumor SUVmax
- D3 D6 n=26 n=32
- D3 D6 - D3 n=26 n=32 n=7
D6 - D1 D4 n=7 n=19 n=19
SUVpeak
- 8.8 8.4 (6.5-10.4) (4.0-14.8)
- 9.0 9.2 - 4.8 (6.3-11.2) (6.8-15.5) (4.0-5.7)
6.3 - 3.5 4.2 (3.9-8.6) (2.1-4.7) (2.5-7.4)
SUVmean
3.3
37 MBq74inj 18 MBq74inj 18 MBq37inj
18 MBq37inj
D6 D0 D1 D4
D0 D3 D6 D0 D3 D6 D0 D3 abcbacd
n=6 n=12 n=12 n=12
n=7 n=6 n=6
n=7 n=6 n=6 n=6 n=6
3.2 3.5 3.2 (3.0-3.9) (3.1-4.2) (1.4-2.4)
3.2 3.5 3.4 3.6 3.2 (3.0-3.8) (3.0-4.1) (3.2-4.1) (3.1-4.1) (1.9-3.8)
3.0 3.4 3.8 3.1 (2.5-3.4) (2.9-3.6) (3.1-4.4) (2.4-3.4)
2.3 1.6 1.5 (1.9-2.4) (1.4-1.7) (1.1-1.6)
2.3 1.6 1.5 1.9 1.5 (2.2-2.4) (1.5-1.7) (1.2-1.6) (1.7-2.8) (0.8-2.1)
1.8 1.8 1.5 1.3 (1.1-1.9) (1.4-2.0) (1.3-1.9) (1.1-1.4)
4.7 3.1 2.7 (4.2-5.7) (2.7-3.3) (2.3-3.0)
4.7 3.0 2.9 4.4 2.4 (4.2-5.7) (2.7-3.2) (2.3-3.0) (3.4-5.1) (1.4-3.2)
2.3 6.5 5.2 4.7 (1.8-2.8) (5.6-8.6) (4.4-7.7) (3.4-6.9)
5.9 5.3 4.9 (5.6-6.5) (4.6-5.7) (4.0-5.8)
5.9 5.3 4.8 6.3 9.7 (5.6-6.4) (4.5-5.7) (4.2-5.8) (5.7-7.6) (7.9-10.6)
10.3 5.6 5.8 5.5 (7.2-11.8) (5.2-6.0) (4.8-6.2) (5.1-6.3)
3.6 3.0 2.6 (2.2-5.4) (1.5-5.7) (1.4-3.9)
3.4 2.9 2.9 3.2 2.2 (2.2-5.4) (1.5-3.9) (1.5-3.9) (1.8-4.9) (0.8-3.8)
2.1 3.2 3.7 3.0 (1.2-4.0) (1.3-5.7) (1.3-5.0) (1.1-5.0)
2.8 1.9 2.2 (2.4-2.9) (1.8-2.8) (1.8-3.1)
2.7 1.9 3.5 2.6 2.3 (2.2-2.9) (1.7-2.7) (2.6-4.1) (2.1-3.0) (1.5-2.8)
2.5 3.9 3.0 3.2 (1.8-3.0) (3.1-4.5) (2.4-4.2) (2.8-4.9)
- 10.7 11.5 (8.2-13.1) (6.8-17.8)
- 11.1 12.7 - 5.5 (7.9-14.3) (8.2-19.8) (4.6-7.0)
7.7 - 4.0 5.1 (4.9-10.6) (2.6-5.1) (3.0-9.0)
- 6.9 7.2 (5.7-7.8) (4.0-10.7)
- 6.3 7.5 (4.7-8.1) (4.7-10.8)
-
3.9 (2.5-4.4) (2.4-5.6)
-
2.2 3.3 (1.7-2.9) (2.0-4.9)
Data is presented as median SUV (interquartile range). SUV calculated as the average of split 1 and split 2. n = number of VOIs per group.
Combined = all VOIs of brain, kidney, lung, spleen and liver, analyzed together as one group.