Page 115 - 89Zr-Immuno-PET:Towards a Clinical Tool to Guide Antibody-based Therapy in Cancer

Noise-induced variability of 89Zr-immuno-PET
CONCLUSION
Based on this study, noise induced variability results in a RC for Zr-89-immuno- PET (37MBq) of less than 6% for manually delineated organs combined, increasing up to 43% at D6 for blood pool and bone marrow, assuming similar biodistribution of mAbs. The signal to noise ratio in Zr-89-immuno-PET scans leads to tumor RC up to 42%.
ACKNOWLEDGEMENTS
We thank Maqsood Yaqub (Department of Radiology & Nuclear Medicine, VU
University Medical Center, Amsterdam, the Netherlands) for the PET analysis
software and Birgit Witte (Department of Epidemiology and Biostatistics, VU 5 University Medical Center, Amsterdam, the Netherlands) for statistical support.
We thank F. Hoffman-La Roche Ltd, Basel, Switzerland for providing support of
the 89Zr-antiCD44 imaging study.
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