Page 65 - Organ motion in children for high-precision radiotherapy - Sophie Huijskens

4.2 | Methods
Patient population
For this retrospective study, we included 20 patients younger than 18 years, treated for various tumors at our radiation oncology department between December 2010 and September 2017 (Table 4.1). Patients were included if a pre-treatment CT scan and multiple CBCT scans of the abdomen or thorax were available, in which the liver, spleen, kidneys, and right and left diaphragm domes were visible (Figure 4.1).
Table 4.1 | Patient characteristics
No. Sex
1 F 2 M 3 F 4 M 5 M 6 F 7 M 8 M 9 M
10 F
11 M 12b M 13 F 14 M 15 M 16 M 17b M 18 M 19 F
Tumor
Sarcoma Medulloblastoma Hodgkin lymphoma Medulloblastoma Medulloblastoma Medulloblastoma Ewing sarcoma Medulloblastoma Spinal metastesis Medulloblastoma Anaplastic glioma Medulloblastoma Neuroblastoma Sarcoma DSRCT Neuroblastoma Medulloblastoma Ewing sarcoma Osteosarcoma
Age at Height Weight diagnosis (cm) (kg)
(years)
11.5 155 38
6.6 110 18 16.5 166 49 14.1 175 36
8.3 128 25
6.7 117 20 16.8 184 62 6.7 129 24 2.6 90 12 7 118 22 7.9 132 31 5.1 109 17 5.3 115 24 10.9 142 37 9.9 137 26 4.7 118 22 4.9 105 18 17.9 182 81 15.1 159 53
No. of CBCTs
RT location
20
M Neuroblastoma 2.2
90 15
5 Thorax
5 Spinal corda 5 abdomen
5 Spinal cord 5 Spinal cord 2 Spinal cord 8 Thorax
5 Spinal cord 8 Thorax
6 Spinal cord 5 Spinal cord 8 Spinal cord 6 Abdomen
5 Thorax
5 Abdomen
6 Abdomen
6 Spinal cord
7 Thorax
5 Thorax
6 Abdomen
Abbreviations: M = male; F = female; DSRCT = desmoplastic small round cell tumor;
a Spinal cord was part of craniospinal irradiation
b Patients 12 and 17 were treated under general anesthesia.; this did not influence interfractional organ position variations
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