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                                Appendix
Chapter 5: SH and EHB were equally responsible for writing and reviewing the manuscript
Chapter 6: JVG, SH, JS were responsible for writing and reviewing the manuscript.
Chapter 7:
Conception and design: EHB
Subject recruitment: SH, ACR, IH van V, GMM, EJMW, JS van der Z, G-JB, EHB Data collection: SH, ACR, IH van V, GMM, EJMW, JS van der Z, G-JB, EHB Statistical analysis and interpretation of data: SH, AHZ, PJS, EHB
Design of tables and figures: SH, AHZ, PJS, EHB
Principal investigator and final responsibility: EHB
All authors were responsible for writing and reviewing the manuscript.
Chapter 8: SH, PJS and EHB were responsible for writing and reviewing the manuscript
Chapter 9:
Conception and design: SH, PB, PJS, EHB
Subject recruitment: SH
Data collection: SH, PB
Statistical analysis and interpretation of data: SH, PB, EHB Design of tables and figures: SH
Principal investigator and final responsibility: EHB
Drafted and revision of paper: SH, PB, PJS, EHB
All authors revised and approved final version manuscript
Funding:
The study described at chapters 3, 7 and 9 was supported by The Netherlands Organization for Health Research and Development (ZonMw). Equipment for the analysis of nitric oxide was provided by Aerocrine-AB in April 2007. The study described at chapter 4 was supported by The Netherland Davos Society. The funding sources had no role in the study design, data collection, analysis or interpretation, or in the decision to submit this article for publication.
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