Page 20 - Bladder Dysfunction in the Context of the Bladder-Brain Connection - Ilse Groenendijk.pdf

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Chapter 1
Part II. Diagnostics and treatment in functional urology.
As explained above, sacral neuromodulation is an often used therapy for OAB, but we can still not predict who will respond to this therapy and who will not. In chapter 5, we investigated whether sacral neuromodulation shows an acute effect on the results of the urodynamic study. We hypothesized, that urodynamics would enable to discrimi- nate between responders and non-responders of sacral neuromodulation directly after implantation. Besides traditional (objective) measurements, the clinical importance of PROMS is increasing, as type and severity of symptoms in patients with OAB can be very heterogeneous. One of the PROMS measuring symptom bother and health-related quality of life in patients with overactive bladder is the OAB-q SF. In chapter 6, this ques- tionnaire was translated and validated in Dutch to make it usable in clinical practice in the Netherlands. A selection of patients with LUT disorders do not show improvement on all available minimally invasive treatments. Given the influence of LUT disorders on quality of life, invasive surgery, like the construction of a continent or incontinent uros- toma, is sometimes inevitable. In chapter 7, the complication rate and reoperation rate of continent catheterizable urinary conduits were measured in all patients undergoing these surgeries in two large academic hospitals in the last 20 years.