Page 16 - Effects and Efficacy of (Laparoscopic) Gastrostomy Placement in Children - Josephine Franken

I. Percutaneous endoscopic versus laparoscopic gastrostomy placement
In chapter 2 a systematic review and meta-analysis is presented comparing laparoscopic GP with the traditional percutaneous endoscopic technique. Primary outcomes are success rate, efficacy of feeding, quality of life, gastroesophageal reflux and postoperative complications.
II. Efficacy and adverse events
In chapter 3 a large retrospective survey is presented analyzing the long-term efficacy and adverse events of GP in a large survey of 300 children. Efficacy of GP is analyzed by method of feeding and weight and length values. Complicatons and reinterventions are meticulously registered. Pre- and postoperative gastroesophageal reflux (GER) symptoms and the value of routine preoperative 24-hour pH monitoring for predicting postoperative GER symptoms are addressed.
III. Gastrointestinal effects
In this part the effects of GP on gastrointestinal function are analyzed. In chapter 4 a prospective, longitudinal cohort study is presented analyzing the effect of GP on gastric emptying in children using the 13C gastric emptying breath test. We investigate whether delayed gastric emptying is related to postoperative gastrostomy failure.
In chapter 5 a prospective, longitudinal cohort study is presented analyzing the effect of GP on the occurrence of GER using 24-hour multichannel intraluminal impedance pH monitoring. We aim to identify predictors of the changes in reflux values after operation. The relationship between GER and GE is investigated.
IV. Health-related quality of life
In this part the effect of GP on health-related quality of life (HRQoL) is analyzed.
In chapter 6 a large retrospective surgey is presented analyzing long-term HRQoL in 128 children after GP. HRQoL was evaluated using the validated Pediatric Quality of Life 4.0 Inventory.
In chapter 7 a prospective, longitudinal cohort study is presented analyzing the effect of GP on HRQoL comparing pre- and postoperative values.
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