Page 119 - Effects and Efficacy of (Laparoscopic) Gastrostomy Placement in Children - Josephine Franken

scale (confidence interval (CI) -2.6 – 8.3; p=0.30). However, analysis of subdomains of HRQoL found that, while physical health scores remained similar after operation (2.4 points; CI -1.7 – 6.3; p=0.24), psychosocial health scores increased significantly (5.4 points; CI 0.5 – 10.3; p=0.03). Further analysis of the subdomains of the psychosocial health scores found that this increase was mainly based on an increase in social scale score (10.1 points; p=0.04). Emotional scale score (2.8 points; p=0.33) and functional scale score (3.4 points; p=0.36) did not increase significantly compared to the preoperative values.
Table 2. Health-related quality of life in children before and after GP.
Chapter 7
Before GP (n = 50)
After GP (n = 40)
Difference (n=40)
Total scale score
54.2 ± 18.6
56.3 ± 20.5
2.1 ± 12.7
Physical Health summary score
45.5 ± 24.2
47.7 ± 28.0
2.1 ± 17.4
Psychosocial Health summary score
55.8 ± 20.8
61.2 ± 19.6
5.5 ± 15.7
emotional scale score
65.4 ± 17.9
68.2 ± 19.2
2.8 ± 18.0
social scale score
58.2 ± 32.3
68.3 ± 27.9
10.1 ± 24.9
Functioning scale score
44.2 ± 28.9
47.6 ± 26.9
3.4 ± 21.1
Legend: Data are presented as mean ± standard deviation.
Predictors of health-related quality of life.
Results of the mixed model of HRQoL are shown in Table 3a (in which pre- and postoperative HRQoL are analyzed in one measure). Children with NI had significantly lower total HRQOL scores compared to children without NI (coefficient -30.5, CI -19.4 – -25.3; p<0.0005). In analysis of subdomains of HRQoL, NI was predictive of both lower physical health scores (coefficient -43.8; CI --57.7 – -29.8; p<0.0005) and lower psychosocial health scores (coefficient -22.6; CI -35.4 – -9.8; p=0.001). Physical health scores increased with higher
Table 3a. Mixed model analysis of health-related quality of life (n=50).
Total HRQoL score
Physical Health summary score
Psychosocial Health summary score
Coefficient (Ci)
p-value
Coefficient (Ci)
p-value
Coefficient (Ci)
p-value
Postoperative (vs. preoperative)
+2.8 (-2.6 – 8.3)
0.30
+2.4 (-1.7 – 6.3)
0.24
+5.4 (0.5 – 10.3)
0.03
Age (years)
+0.9 (0.2 – 2.0)
0.09
+1.8 (0.5 – 3.2)
0.008
+0.2 (-1.0 – 1.4)
0.70
BMi (kg/m2)
-0.4 (-2.4 – 1.7)
0.73
+1.0 (-1.5 – 3.5)
0.42
-1.1 (-3.4 – 1.2)
0.34
ni (yes/no)
-30.5 (-41.6 – -19.4)
<0.0005
-43.8 (-57.7 – -29.8)
<0.001
-22.6 (-35.4 – -9.8)
0.001
Cardiac (yes/no)
-19.9 (-43.2 – 3.4)
0.09
-25.9 (-55.0 – 3.3)
0.08
-15.2 (-41.8 – 11.5)
0.26
Complication(s)
+1.3 (-2.0 – 4.7)
0.43
+1.4 (-3.0 – 5.9)
0.52
+0.7 (-3.4 – 4.8)
0.75
Legend: BMI body mass index; CI confidence interval; HRQoL health-related quality of life; NI neurologic impair- ment
117