Page 107 - Effects and Efficacy of (Laparoscopic) Gastrostomy Placement in Children - Josephine Franken
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Figure 2 shows HRQoL after GP stratified according to our main categories of morbidity. Lowest HRQoL values were found in NI children (45.8 ± 18.1), followed by children with cardiac disease (50.9 ± 23.1), cystic fibrosis (68.5 ± 15.1), behavioral disorder (72.5 ± 21.9), failure to thrive (74.5 ± 18.5) and renal disease 75.2 (± 18.9).
Figure 2. HRQoL stratified according to disease category.
Legend: HRQoL: Health-related quality of life. Bars are depicted in means with standard deviations. The dot- ted line represents the mean HRQoL of a healthy child population, as measured by Varni et al (82.70 ± 15.40). Neurologic impairment 45.8 (± 18.1); Cardiac disease 50.9 (± 23.1); Cystic fibrosis 68.5 (± 15.1); Behavioral disorder 72.5 (± 21.9); FTT Failure to thrive 74.5 (± 18.5); Renal disease 75.2 (± 18.9).
Predictors of HRQoL outcome after GP
All variables included in the multiple regression model of postoperative HRQoL and their coefficients are shown in Table 4. These results are based on the imputed data (n=150).
Patients with NI had a significantly lower postoperative HRQoL compared to the rest of the patients with normal neurodevelopment (NN), with a mean of 46.4 (± 18.2) in NI children compared to 71.4 (± 15.9) in NN children (confidence interval of the difference 23.8 – 26.5). Furthermore, NI had the highest predictive value of lower HRQoL outcome out of all variables included in the multivariable analysis, with an adjusted mean difference of 21.4 points (32.6 – 10.3) between NI and NN children. In subdomains of HRQoL, NI children scored particularly lower in the domain of physical health, with a mean physical health score of 27.5 (± 27.6) in NI children versus 71.3 (± 21.2) in NN children, with a mean difference of 43.8 points (41.8 – 45.9).
In the psychosocial domain, NI children had a smaller disadvantage compared to NN children, with a mean psychosocial health score of 56.8 (± 17.2) in NI children compared to 70.6 (± 15.5) in NN children, with a mean difference of 13.7 points (12.4 – 15.1).
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