Page 91 - Biomarkers for risk stratification and guidance in heart failure
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Chapter 4
Interaction P = 0.016
HFrEF
HFpEF
BNP-guided # events
Control
# events
787 708 558 355 58 94 121 793 699 525 377 71 124 154
136 147 135
139 154 167
115 109 20 24 128 117 12 22
75 40 33 37 87 34 25 32
Figure 1 Kaplan - Meier curves of survival comparing patients allocated to (N-terminal pro-)brain natriuretic peptide (NT-proBNP)-guided treatment or control group with reduced left ventricular ejection fraction (HFrEF)) and preserved left ventricular ejection fraction (HFpEF).
HFrEF
HFpEF
Figure 2 Forest plot of the primary endpoint, overall mortality, showing unadjusted individual and mean hazard ratios with 95% confidence intervals for seven studies providing individual patient data of patients with heart failure with reduced ejection fraction (HFrEF) and four studies also including patients with heart failure with preserved ejection fraction (HFpEF). BNP-guided, (N-terminal pro-)brain natriuretic peptide (NT-proBNP)-guided treatment.
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