Page 56 - Biomarkers for risk stratification and guidance in heart failure
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Management of chronic heart failure guided by individual NT-proBNP targets.
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Table 2. Secondary outcome measures in the overall study population and in subgroups.
Overall
NT-proBNP-guided Clinically-guided NT-proBNP-guided Clinically-guided NT-proBNP-guided Clinically-guided NT-proBNP-guided Clinically-guided NT-proBNP-guided Clinically-guided NT-proBNP-guided Clinically-guided NT-proBNP-guided Clinically-guided NT-proBNP-guided Clinically-guided NT-proBNP-guided Clinically-guided
174 99.0(74.4–100.0) 0.174 46(26) 171 98.5(64.4–99.9) 57(33) 112 99.2(82.2–100.0) 0.140 28(25) 117 98.6(57.3–99.9) 39(33) 42 97.3(42.8–99.7) 0.946 13(31) 42 98.0(82.3–99.6) 13(31) 87 97.5(43.8–99.7) 0.325 31(36) 85 92.9(33.6–99.5) 41(48) 87 99.7(96.8–100.0) 0.248 15(17) 86 99.2(95.4–99.9) 16(19) 92 99.5(95.4–100.0) 0.114 17(18)
81 98.7(88.6–99.9) 21(26)
82 97.9(42.2–99.9) 0.908 29(35)
90 96.6(50.6–99.8) 36(40) 85 99.7(97.8–100.0) 0.076 11(13)
80 99.4(96.4–100.0) 16(20)
81 95.4(37.0–99.6) 0.742 32(40)
82 93.0(33.8–99.3) 37(45)
0.206 0.164 0.861 0.139 0.845 0.225 0.745 0.198 0.656
34(20) 36(21) 20(18) 25(21) 12(29) 9(21) 21(24) 24(28) 13(15) 12(14) 13(14) 13(16) 21(26) 23(26) 7(8) 12(15) 24(30) 21(26) to the
0.705 0.439 0.421 0.504 0.853 0.653 0.874 0.157 0.561
0.68(0.00–4.56) 0.93(0.14–4.62) 0.48(0.00–4.42) 0.93(0.07–0.51) 1.67(0.16–8.52) 1.04(0.30–4.73) 2.19(0.17–8.47) 1.23(0.16–7.91) 0.24(0.00–2.05) 0.55(0.00–3.16) 0.37(0.00–2.71) 0.93(0.14–3.83) 1.23(0.10–7.83) 0.88(0.10–4.96) 0.27(0.00–1.39) 0.55(0.00–2.71) 2.33(0.16–9.82) 1.85(0.17–8.41)
0.490 0.334 0.760 0.897 0.196 0.138 0.587 0.116 0.804
LVEF ≤45%
LVEF >45%
NT-proBNP >2,950 pg/ml
NT-proBNP ≤2,950 pg/ml
Age ≤74 yrs
Age >74 yrs
Discharge creatinine ≤123 U/l
Discharge creatinine >123U/l
Group
N Median (IQR) P-value N (%)
P log rank
N (%)
P log rank
Median (IQR)
P-value
*The number of days alive outside the hospital
Hosp=hospitalization; IQR=interquartile range. Other abbreviations as in table 1.
Days alive outside hosp*
Mortality
CV mortality
Days admitted hosp†
as a percentage of
total days of follow-up. †days admitted
hospital as a percentage of total days alive.
