Page 120 - Biomarkers for risk stratification and guidance in heart failure

Serial NT-proBNP measurements during and early after HF admission.
CONCLUSION
For adequate individual risk assessment early after hospital discharge, knowledge of serial NT-proBNP values is important. Early changes in NT-proBNP concentration after admission because of HF, the extent of decrease in NT-proBNP concentration during admission and the absolute NT-proBNP concentration 1 month after hospital discharge are independent prognostic parameters. They may help to further individualize risk of readmission because of HF or mortality. Even relative small early outpatient changes in NT-proBNP are associated with outcome, suggesting that biologic variability is small and that changes in these levels do reflect underlying pathophysiologic processes. Knowledge of individual risk might lead to an individualized treatment approach, and the effect of such an approach should be assessed in future randomized trials.
Disclosures
LE received consultancy fees from Roche Diagnostics. HPB and YP received unrestricted grants and consultancy fees from Roche Diagnostics.
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