Page 107 - Biomarkers for risk stratification and guidance in heart failure

Chapter 5
characteristics at baseline and 1 month after hospital discharge are presented in Table 1. Patients were overall elderly and predominantly male, more than one- half had coronary artery disease, and about one-half had an ischemic etiology of HF. At admission because of acute HF, median NT-proBNP concentration was clearly elevated, and during admission the median decrease in NT-proBNP concentration was >60%. One month after hospital discharge, median NT-proBNP concentration was 2,538 pg/mL.
Table 1. Baseline Characteristics of the Overall Population and According to Composite NT-proBNP Score Group
Baseline
Age, y
Female
BMI, kg/m2 Hypertension Diabetes mellitus Stroke or TIA Peripheral artery disease
COPD
Atrial fibrillation Coronary artery disease Myocardial infarction
PCI
CABG
Valve replacement Pacemaker
ICD
Mitral regurgitation ≥II
Previous episode of HF
Ischemic cause
of HF
72.0 (12.0) 132 (42.7) 25 (4.8) 153 (49.5) 86 (27.8) 55 (17.8) 58 (18.8)
53 (17.2) 97 (31.4) 182 (58.9)
124 (40.1)
36 (11.7) 54 (17.5) 20 (6.5) 28 (9.1) 20 (6.5) 135 (48.2)
108 (35.0) 141 (45.8)
68.4 (12.2) 30 (48.4) 24.8 (4.7) 31 (50.0) 15 (24.2) 12 (19.4) 9 (14.5)
9 (14.5) 14 (22.6) 28 (45.2)
11 (17.7)
3 (4.8)
8 (12.9) 1 (1.6)
2 (3.2)
1 (1.6) 26 (44.1)
10 (16.1) 17 (27.4)
70.0 (11.0) 39 (41.5) 25.6 (4.6) 50 (53.2) 22 (23.4) 18 (19.1) 20 (21.3)
18 (19.1) 29 (30.9) 49 (52.1)
33 (35.1)
13 (13.8) 13 (13.8) 2 (2.1)
6 (6.4)
4 (4.3) 42 (48.3)
25 (26.6) 43 (45.7)
75.1 (12.6) 35 (42.2) 24.1 (4.7) 33 (39.8) 20 (24.1) 14 (16.9) 18 (21.7)
14 (16.9) 26 (31.3) 58 (69.9)
43 (51.8)
8 (9.6) 16 (19.3) 5 (6.0)
9 (10.8) 5 (6.0) 41 (56.2)
31 (37.3) 45 (54.2)
74.4 (11.2) .001 28 (40.0) .782 25.6 (5.2) .213 39 (55.7) .191 29 (41.4) .040 11 (15.7) .924 11 (15.7) .571
12 (17.1) .905 28 (40.0) .200 47 (67.1) .005
37 (52.9) <.001
12 (17.1) .130 17 (24.3) .241 12 (17.1) <.001 11 (15.7) .057 10 (14.3) .014 26 (42.6) .391
42 (60.0) <.001 36 (52.2) .007
106
Patient Characteristic
Overall (n = 309)
Group 1: 0 Points (n = 62)
Group 2: 1 Point (n = 94)
Group 3: 2 Points (n = 83)
Group 4: 3 Points (n = 70)
P Value (Overall)