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Part II Chapter 7 Chapter 8 Chapter 9 Chapter 10 Chapter 11 Addendum Clinical application 145 Impact of Partial-Volume Correction in Oncological PET 147 Studies: A Systematic Review and Meta-Analysis. Eur J Nucl Med Mol Imaging. 2017 Nov;44(12):2105-2116. Prognostic Value of [18F]-Fluoromethylcholine PET- 173 CT before Stereotactic Body Radiation Therapy for Oligometastatic Prostate Cancer. Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):406-410. Methodological Considerations for Response Assessment 185 using [18F]FDHT and [18F]DCFPyL PET-CT in Castration- Resistant Prostate Cancer: A Clinical Illustration. Adapted from Mol Imaging Biol (2019). https://doi.org/10.1007/s11307-019-01438-y Prostate-Specific Membrane Antigen Expression Measured 197 on Positron Emission Tomography as a Novel Biomarker in Primary Prostate Cancer. To be submitted. Summarizing discussion and future perspectives 205 Nederlandse samenvatting 231 Acknowledgements 240 List of publications 244 Abbreviations 247 Curriculum Vitae 250