Page 202 - Quantitative Imaging of Small Tumours with Positron Emission Tomography

PSMA: a novel biomarker in primary prostate cancer Conclusion These emerging data may indicate that PSMA-expression might be an additional biomarker to PSA, biopsy pathology characteristics, and tumour stage in the pre- treatment stratification of primary PCa patients. The predictive value of PSMA- expression on PET seems to be valid using both basic PET analysis (5) and radiomics analysis (3,4), and using both [18F]-labelled and [68Ga]-labelled PSMA- ligands, and may even outperform existing prediction models. In clinical practice, PSMA PET can initially be used in intermediate- to high-risk patients to visually exclude distant metastases, and subsequently to predict the risk of LNI through quantification of PSMA-expression in the primary tumour. We acknowledge that current datasets are relatively small and that external model validation is lacking. Larger multicenter cohort studies are needed to validate these findings and develop robust prediction models. 10 201