Page 62 - 18F-FDG PET as biomarker in aggressive lymphoma; technical and clinical validation
P. 62
Chapter 3
Fig. 3 Summary receiver operating curves (sROC) for different visual interim PET criteria.
Studies that assessed interim PET scans according to the Deauville’s criteria are indicated with blue circles, studies that used the international harmonization project (IHP) criteria are indicated with red diamonds and studies that used custom visual criteria are indicated with green squares. The size of the circles, diamonds, and squares are based on the inverse standard error
Negative predictive values for 2-year progression-free status were generally above 80%, except in four studies [34,35,39,53]. In Mamot et al. [39], the somewhat lower negative predictive value could possibly be explained because radiotherapy (administered regardless of PET results) was counted as an event and resulted in a lower EFS rate compared to other clinical trials. Zhao et al. [53] had a low percentage of negative interim PET scans and a high number of events, which explains the lower NPV.
60
