Page 163 - 18F-FDG PET as biomarker in aggressive lymphoma; technical and clinical validation

Rituximab intensification during R-CHOP in DLBCL
and OS had not been reached in either arm. The 3-year FFS rate was 74% (95% CI, 68% to 78%) in the R-CHOP-14 arm versus 69% (95% CI, 63% to 74%) in the RR-CHOP-14 arm (HR, 1.26; 95% CI, 0.98 to 1.61; P = .07; adjusted for age group and age-adjusted IPI score; Fig 2A); FFS rates at 5 years were 68% (95% CI, 62% to 73%) and 62% (95% CI, 56% to 67%), respectively. PFS at 3 years
Fig. 1. CONSORT diagram of induction treatment of patients with diffuse large B-cell lymphoma in the HOVON-84 non-Hodgkin lymphoma trial by treatment arm.
CR, complete remission; R1, induction randomization; R2, maintenance randomization; R-CHOP, rituximab on day 1 of each cycle plus cyclophosphamide, doxorubicin, vincristine, and prednisone (arm A); RR-CHOP, rituximab on days 1 and 8 of first 4 cycles and day 1 of remaining cycles plus cyclophosphamide, doxorubicin, vincristine, prednisone (arm B).
161
6b