Page 112 - 18F-FDG PET as biomarker in aggressive lymphoma; technical and clinical validation
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Chapter 5 Table1.Interobserverreliabilityofsemi-automatedMTVandTLGassessmentforthedifferentworkflows.
MTV
Workflow A (individual lesion selection)
41%MAX 1106 65.54 (33-4991) (0-164.38)
A50%P 550 36.74 (34-4153) (0-139.73)
SUV≥2.5 2399 13.34 (73-7404) (0-54.21)
SUV≥4.0 1289 13.78 (30-5688) (0-83.59)
MV2 1505 22.68 (59-6258) (0-83.59)
MV3 927 33.54 (33-4654) (0-154.17)
Workflow B (automated preselection
SUV≥4.0, 1004 2.32 Volume≥3ml (23-5723) (0-10.43)
0.43 (0.08-0.76)
0.86 (0.68-0.95)
0.96 (0.91-0.99)
0.94 (0.86-0.98)
0.92 (0.80-0.97)
0.91 (0.79-0.97)
1.00 (1.00-1.00)
TLG
6236 (471-21431)
5736 (245-45441)
15902 (347-55588)
13617 (220-50068)
14422 (301-51908)
12181 (229-43669)
8446 (189-50779)
54.57 0.37 (0-151.84) (0.02-0.72)
26.76 0.93 (0-118.26) (0.82-0.98)
7.11 0.99 (0-33.81) (0.98-1.00)
11.32 0.97 (0-82.52) (0.93-0.99)
15.84 0.97 (0-82.52) (0.91-0.99)
24.91 0.96 (0-135.92) (0.89-0.99)
1.85 1.00 (0-7.49) (1.00-1.00)
13.33 0.97 (0-111.83) (0.93-0.99)
Workflow C (automated preselection with manual modification)
Final MTV 1115 16.71 0.92 8610 (53-5589) (0-109.46) (0.82-0.98) (284-48079)
MV, Majority Vote; MTV, metabolic tumor volume; CoV, coefficient of variation; ICC, intraclass correlation coefficient; CI, confidence interval; TLG, total lesion glycolysis.
Table 2. Mean analysis time for the different workflows in minutes (mean ± standard deviation (range)).
Workflow
Observer 1 Observer 2 Observer 3 Mean
A individual lesion selection (n=12)
29.1±20.8(5-63) Not reported* 28.2±13.7(15-60) 28.7†
B automated preselection (n=12)
7.2±3.7(3-15) Not reported* 7.3±3.5(1-12) 7.3†
C with manual modification (n=12)
23.3±13.4(5-45) 26.7±15.6(10-62) 16.7±9.7(8-42) 22.2
*Observer 2 summed the total time for workflow A + B; mean 27.3±19.2 (7-75) minutes. †Mean value based on 2 observers.
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Mean Mean CoV ICC Mean Mean CoV ICC (range) (range) (95%CI) (range) (range) (95%CI)
