Page 11 - Tyrosine-Based Bioconjugations - Jorick Bruins

Abstract:
Here, we introduce topics related to the research discussed in this thesis. The first part will discuss antibodies, and touch upon their structure and function (section 1.1.), bispecific and trispecific antibodies (section 1.1.2.), and antibody conjugates (section 1.1.3.). Subsequently, several types of antibody conjugation strategies are discussed (section 1.2.), which is followed up by a brief introduction of the enzyme mushroom tyrosinase (section 1.3.). This is followed up by a review regarding quinones and derivatives thereof (section 1.4.), and is finalized by an overview of the SPOCQ reaction (section 1.5.) and the aim of using the SPOCQ reaction in this thesis (section 1.6.).
Part of this work was published as:
Jorick J. Bruins, Bauke Albada, Floris L. van Delft, Chem. Eur. J. 2018, 24, 4749−4756.