Page 78 - Fertility in Women with Rheumatoid Arthritis Vruchtbaarheid van vrouwen met reumatoïde artritis

Chapter 5
Table 1. Patient characteristics at time of diagnosis*
Age - years BMI - kg/m2
Missing
Duration of symptoms - days
RF positive - no. (%) Missing
Anti-CCP positive - no. (%) Missing
CRP - mg/L
DAS-28 - mean (± SD) Erosions positive - no. (%)
Patients for analysis
(n=72)
35.1 (30.1 – 39.2) 24.2 (21.9 – 28.3) 2
115 (67 – 182) 33 (46)
-
39 (54)
-
7.0 (3.3 – 16.0) 4.52 (±1.29) 10 (14)
Patients without available serum**
(n=22)
34.4 (29.6 – 38.7) 23.7 (22.1 – 32.7) 2
124 (75 – 306) 8 (47)
5
7 (41)
5
11.0 (4.0 – 20.0) 5.18 (±1.07)
2 (9)
P-Value
0.681† 0.531†
0.500† 1.000‡
0.422‡
0.167† 0.032§ 0.726‡
*Except where indicated otherwise, values are the median (interquartile range).
**Patients without available serum at T0 were excluded from further analyses.
BMI = body mass index, RF = rheumatoid factor, anti-CCP = anti-cyclic citrullinated peptide, CRP = C-reactive protein, DAS-28 = disease activity score with a 28 joint count.
P-values indicate differences between the two groups, as calculated by (†) Mann Whitney-U test, (‡) Fisher’s exact test and (§) Student’s t-test
AMH at time of diagnosis
At T0, the median age in patients was higher than in controls (35.1 (30.1-39.2) and 29.4 (23.8-34.3) years respectively, p<0.001). BMI did not differ signi cantly (24.2 (21.9-28.3) and 22.9 (21.2-25.7) kg/m2, p=0.063). Median AMH values were 1.71 (0.81-4.39) μg/L in patients and 2.82 (1.64-4.38) μg/L in controls. When adjusted for age, AMH values did not differ signi cantly between patients and controls (p=0.254). Eight patients (11%) had AMH levels below the 10th percentile of controls ( gure 1A).
There was no signi cant difference in AMH levels, adjusted for age, when comparing RF positive with RF negative women (p=0.487). No differences in AMH concentrations were found between anti-CCP positive and negative women (p=0.686). AMH levels were not signi cantly different when erosions were present (p=0.350). Finally, there was no signi cant correlation between AMH and either CRP (r=-0.207, p=0.083) or DAS28 (r=0.007, p=0.955).
76