Page 49 - Fertility in Women with Rheumatoid Arthritis Vruchtbaarheid van vrouwen met reumatoïde artritis

Table 1 - Characteristics of participants and non-participants
Fertility in RA – fertility assessments
Current age (years)
missing
Education level
Low
Intermediate High missing
At start of last PARA episode
Age during PARA (years) missing
Number of previous children mean
missing
Smokers
missing Duration of RA in years
RF positivity **
missing
ACPA positivity **
missing
Periconceptional DAS28 ** missing
Obstetric outcome of last PARA participation
Achieved pregnancy
Life birth*
Miscarriages*
Maternal complications* Neonatal complications*
Nulliparous at end PARA study missing
Participants (n=178)
40.5 ± 4.2 1 (0.6%)
11 (6.2%) 74 (42%) 93 (52%) -
32.4 ± 4.0 2 (1.1%) 1 (0–1) 0.61 ± 0.63 -
12 (6.7%) 2 (1.1%) 15.0 ± 6.6 129 (72%) 4 (2.2%) 114 (64%) 1 (0.6%) 3.7 ± 1.2 17 (9.6%)
147 (83%) 143 (97%) 4 (2.7%) 39 (27%) 24 (16%) 16 (9.0%) 1 (0.6%)
Non-participants (n=82)
40.6 ± 4.3 -
5 (6.1%) 18 (22%) 28 (34%) 31 (38%)
32.5 ± 4.0 -
0 (0–1) 0.59 ± 0.72 1 (1.2%) 18 (22%) 2 (2.4%) 13.7 ± 5.9 59 (72%) 1 (1.2%) 55 (67%) 1 (1.2%) 3.5 ± 1.3 4 (4.8%)
52 (63%) 50 (96%) 1 (1.9%) 12 (23%) 7 (13%) 20 (24%) 2 (2.4%)
p-value
0.834 ƚ 0.51§¥
0.905 ƚ 0.55β
<0.001ǂ 0.135 ƚ
0.826ǂ 0.584ǂ 0.394 ƚ
0.001 ǂ 0.653 ¥ 1.000 ¥ 0.715 ¥ 0.824 ǂ 0.002 ¥
3
Values are given as mean ± S.D., number(%), and median (interquartile range). * As a percentage of achieved pregnancies during last PARA participation. ** At the start of last PARA participation. P-values were calculated using ƚ unpaired T-test, ǂ Chi2 test, ¥ Fisher’s Exact test (§ on non-missing data), and β Mann-Whitney U test. PARA=pregnancy-induced amelioration of rheumatoid arthritis; RA= rheumatoid arthritis; RF = rheumatoid factor; ACPA = anti-citrullinated protein antibodies; DAS28 = disease activity score with a 28 joint count.
(median 2 (IQR 1-2, mean 1.9±0.78) per woman), with a maximum of 4 children per woman. Nine women (5%) remained nulliparous, of whom six (3% of participants) had never been pregnant and three women (2%) had only had pregnancies resulting in a miscarriage.
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