Page 35 - Fertility in Women with Rheumatoid Arthritis Vruchtbaarheid van vrouwen met reumatoïde artritis

Table 2 – Differences between subfertile and fertile female patients with rheumatoid arthritis
Fertility in RA – clinical factors
Variable
Age, years
Nulliparity, n (%)
Smoking, n( %)
Duration of RA, years
RF positive, n (%)
ACPA positive, n (%) Erosions present, n (%)
MTX in past, n (%) Biologicals in past, n (%) DAS28
NSAIDs, n (%)
Prednisone, n (%) Sulfasalazine, n (%) Spontaneous abortion, n (%)
Yes (n=104)
31.9±4.3 67 (64) 15 (14) 3.7 (1.1-8.8) 83 (80) 76 (73) 52 (50) 67 (64) 16 (15) 4.01±1.16 35 (34) 46 (44) 35 (34) 11 (11)
No (n=141)
30.8±3.5 76 (54) 19 (13) 3.4 (1.5-7.9) 97 (69)
85 (60) 70 (50) 94 (67) 21 (15) 3.47±1.10 25 (18) 35 (25) 44 (31) 15 (11)
p value
0.029 † 2
0.116 ‡ 0.853 ‡ 0.589 ¶ 0.058 ‡ 0.042 ‡ 1.000 ‡ 0.786 ‡ 0.527 ‡
<0.001 † 0.007 ‡ 0.002 ‡ 0.782 ‡ 1.000 ‡
Subfertility*
* Subfertility is de ned as a time to pregnancy >12 months. Values are given as mean±SD, median (IQR) and no.(%).
† Student’s t test.
‡ Fisher’s exact test.
¶ Mann-Whitney U test.
ACPA, anti-citrullinated peptide antibodies; DAS28, 28-joint Disease Activity Score; MTX, methotrexate; NSAIDs, non-steroidal anti-inflammatory drugs; RA, rheumatoid arthritis; RF, rheumatoid factor.
Table 3 – Cox regression analysis for occurrence of pregnancy in female patients with rheumatoid arthritis
Variable HR
Age (per year) 0.96
Nulliparity 0.52
Smoking 0.89
Disease duration (per year) 1.00
RF positivity 0.84
ACPA positivity 0.79
DAS28 (per point) 0.81
NSAIDs 0.66
Prednisone 0.61
Sulfasalazine 0.83
Past use of MTX 1.35 0.99 to 1.84
95% CI
p Value
0.038 <0.001 0.585 0.685 0.369 0.212 0.002 0.022 0.002 0.234 0.059
0.92 to 1.00 0.38 to 0.70 0.57 to 1.37 0.98 to 1.03 0.57 to 1.23 0.55 to 1.14 0.71 to 0.93 0.46 to 0.94 0.45 to 0.83 0.62 to 1.13
ACPA, anti-citrullinated peptide antibodies; DAS28, 28-joint Disease Activity Score; MTX, methotrexate; NSAIDs, non-steroidal anti-inflammatory drugs; RF,rheumatoid factor.
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