Page 97 - Molecular features of low-grade developmental brain tumours

Tumour mTOR
size AED** inhibitors Other clinical manififistations
(mm)
4
THE CODING AND NON-CODING TRANSCRIPTIONAL LANDSCAPE OF SEGA
42 yes
no unknown
unknown
31 yes
no no
no yes (non
responder) yes (res-
ponder) no
no no
no no
no no no no
no
no
no
no no no
no other signs for TSC cortical tuber, AML
cortical tuber
multiple SEGAs,cortical tubers, drug resistant epilepsy
tubers, minor psychomotor delay, SEN
renal cysts
cortical tuber
unknown
no other signs for TSC cortical tuber
cortical tuber unknown
minor psychomotor delay none
cortical tuber
cortical tubers, autism, drug resistant epilepsy, behaviour
problems (aggressivity)
minor psychomotor delay, cortical tubers
unknown
cortical tubers, mild angiofifibroom
multiple SEGAs, cortical tubers, drug resistant epilepsy
no 40 yes
30 yes
20 yes
5 no
5 yes
45 yes
27 no 30 yes
20 yes 40 yes 30 yes 30 yes
unknown
no
30 yes
20 yes
34 yes
42 no 30 yes
from same patient; ** The most commonly used AEDs are carbamazepin, vigabatrin, valproate and topiramate, however each patient had a personalized drug treatment regime.
95