Page 66 - Molecular features of low-grade developmental brain tumours

3
CHAPTER 3
S46b
S47b S48b
S49b
S50b
S51b S52b
S53b
S54b
S55b C1a,b
C2a,b C3a,b C4a,b
C5a
C6a C7a,b
C8a
C9b C10b C11b
SEGA
SEGA SEGA
SEGA
SEGA
SEGA SEGA
SEGA
SEGA
SEGA control
control control control control control control control control control control
10
9 15
4
3
17 13
15
15
24 2
13 7 2 17 15 44 56 1 3 17
Male
Female Female
Female
Female
Female Male
Female
Male
Male Female
Male Female Male Female Male Female Male Female Female Female
TSC2
TSC1 TSC2
TSC1
TSC2
TSC2 TSC2
NMI
TSC1 TSC2
control control control control control control control control control control control
ND
ND ND
ND
ND
ND ND
ND
ND
ND control
control control control control control control control control control control
ventricle 45 no yes thirdventricle 30 no no
d f o r m group based on methylation.
S E G A s a m p l e s u s e
SEN = subependymal nodule; NMI = no mutation identifified; ND = not defifined, u.k = unknown.*Sub -
e t h y l a t i o n
a n a l y s i s a a n d i m m u n o
h i s t o c h e m i s t r y b . A E D =
a n t i e p i l e p t i c d r u g s ;
foramen 10 no monro
ventricle u.k. no
yes yes
yes
no yes
caudate nucleus
ventricle ventricle
frontallobe, interhemisp- heric
ventricle
thirdventricle
peri- ventricular
peri- ventricular
peri- ventricular
peri- ventricular
peri- ventricular
peri- ventricular
peri- ventricular
peri- ventricular
peri- ventricular
peri- ventricular
peri- ventricular
20 yes
27 no 20 yes
50
33 no yes
22
N/A N/A
N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
no no
no no N/A
N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
64