Page 63 - Molecular features of low-grade developmental brain tumours

Age at epilepsy onset
Seizure freq.
AED
Type of AED
mTOR Other clinical
inhi- manifestations bitors
3
324 10
12 N/A N/A N/A 1
3 4
3
204
372 u.k.
u.k.
u.k.
u.k.
u.k. 6
12 N/A
6 24
yearly daily
u.k. N/A N/A N/A daily
no no
daily mont-
hly u.k. u.k.
u.k.
u.k.
u.k.
u.k. weekly
weekly N/A
daily mont-
hly
yes yes
u.k. N/A N/A N/A yes
yes yes
yes yes
yes u.k.
u.k.
u.k. yes
u.k. yes
yes N/A
yes yes
Valproic acid, Carbamazepine yes Vigabatrin no
u.k. u.k. N/A N/A N/A N/A N/A N/A
Vigabatrin, Valproic acid,Topiramate, no Carbamazepine, Adrenocorticotropic
Hormone,Levetiracetam, Phenytoin Vigabatrin, Valproic acid,Topiramate no
Vigabatrin, Valproic acid no Vigabatrin,Valproic acid,Lamotrigine no
,Oxcarbazepine
u.k. no
u.k. no u.k. u.k.
u.k. u.k.
u.k. no VP-Shunt, Carbamazepine, no
Gabapentin
u.k. no
Topiramate yes Phenobarbital, Carbamazepine no
N/A N/A Clonazepam, Carbamazepine, no
Valproic acid
Carbamazepine no
Tubers, SEN, Angiomyolipoma
Tubers, SEN, Rhabdomyoma, learning impairment
Angiomyolipoma
Angiomyolipoma
no other signs of TSC
Tubers, mild angiofifibroom
Tubers, angiomyolipoma, autism
Tubers, angiomyolipoma, autism
Tubers, Angiomyolipoma Tubers, angiomyolipoma,
autism Angiomyolipoma, learning
impairment Adenoma sebaceum
Numerous white spots a the back
Suspected cardial Rhabdomyoma, multiple hypopigmentations, Angiofifibroma
Tubers
Tubers
Tubers Tubers, SEN, minor
psychomotor delay Minor psychomotor delay
DISTINCT DNA METHYLATION PATTERNS IN SEGA IN TSC
no other signs of TSC Tubers, minor
psychomotor delay no other signs of TSC
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