Page 39 - Molecular features of low-grade developmental brain tumours

Chapter two
Subependymal giant cell astrocytomas in tuberous sclerosis complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations
Bongaarts A1*, Giannikou K2*, Reinten RJ1, Anink JJ1, Mills JD1, Jansen FE3, Spliet WGM4, den Dunnen WFA5, Coras R6, Blümcke I6, Paulus W7, Scholl T8, Feucht M8, Kotulska K9, Jozwiak S10, Buccoliero AM11, Caporalini C11, Giordano F12, Genitori L12, Söylemezoğlu F13, Pimentel J14, Nellist M15, Schouten-van Meeteren AYN16, Nag A17, Mühlebner A1,8, Kwiatkowski DJ2†, Aronica E1,18,19†
1.Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. 2. Division of Pulmonary and Critical Care Medicine and of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. 3. Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, The Netherlands. 4. Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. 5. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 6. Department of Neuropathology, University Hospital Erlangen, Erlangen, Germany. 7. Institute of Neuropathology, University Hospital Münster, Münster, Germany. 8. Department of Pediatrics, Medical University of Vienna, Vienna, Austria. 9. Department of Neurology and Epileptology, Children’s Memorial Health Institute, Warsaw, Poland. 10. Department of Child Neurology, Medical University of Warsaw, Warsaw, Poland. 11. Pathology Unit, Anna Meyer Children’s Hospital, Florence, Italy. 12. Department of Neurosurgery, Anna Meyer Children’s Hospital, Florence, Italy. 13. Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. 14. Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal. 15. Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands. 16. Department of Pediatric Oncology, Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 17. Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, MA. 18. Stichting Epilepsie Instellingen Nederland (SEIN), The Netherlands. 19. Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands. *Authors contributed equally to the present work. †These authors share the senior authorship
Oncotarget. 2017 Nov 10; 8(56): 95516–95529