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Figure 4. Karnofsky performance status.
Multivariate analysis of risk factors
A multivariate Cox regression analysis was performed by employing as risk factors primary tumor (Tomita modified, moderate growth HR 1.7, 95%CI 0.9- 3.3, p=0.099, fast growth HR 3.1, 95%CI 1.6-6.2, p=0.001), presence of visceral metastases (HR 1.7, 95%CI 1.0-2.9, p=0.033) and performance status (KPS 50- 70 HR 1.3, 95% CI 0.8-2.1, p=0.292, KPS 10-40 HR 2.7, 95%CI 1.1-6.6, p=0.025) (table 7).
Table 7. Results of multivariate Cox-regression analysis. HR: Hazard ratio; 95% CI: 95% confidence interval
Tomita tumor classification
Slow 0.004
SURGICAL COHORT
III
Multivariate analysis
HR
p-value
95% CI
Moderate 1.7 Fast 3.1
Visceral metastasis
Present/not present 1.7
0.099 0.9-3.3 0.001 1.6-6.2
0.033 1.0-2.9 80-100 0.077
Karnofsky performance status
50-70 1.3 40-10 2.7
0.292 0.8-2.1 0.025 1.1-6.6
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