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Promotor Prof. dr. T.A.M.J. van AmelsvoortCo-Promotors Dr. H.J.G. Boot, ’s Heeren Loo and Maastricht University Dr. A.M. van Eeghen, ’s Heeren Loo and University of AmsterdamAssessment Committee Prof. dr. D.E.J. Linden (voorzitter) Dr. D.A.M. Maes – Festen (Erasmus Medical Center, Rotterdam, The Netherlands) Prof. dr. D.M. McDonald-McGinn (Perelman School of Medicine of the University of Pennsylvania, Philadelphia, United States of America) Em. Prof. dr. C.T.R.M. Stumpel The research presented in this thesis was performed at Advisium (Expert Center for Genetic syndromes), ‘s Heeren Loo, Amersfoort, The Netherlands and the Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands. This work was supported financially by Stichting Wetenschappelijk Onderzoek, ‘s Heeren Loo