Page 237 - Demo

Summary235A1psychiatric burden. Systematic studies in individuals with 22q11.2DS are needed to improve diagnosis, using strategies adjusted to their cognitive profile and including attention for seemingly innocuous life events that may be traumatic, and to evaluate the efficacy of treatments in this population.In chapter 8 results of individual studies of this thesis are discussed in a broader context and in relation to previous research. Collectively, studies included in this thesis seem to point to precocious aging in adults with 22q11.2DS. In addition, this chapter provides recommendations for future research, including longitudinal studies over the life course of individuals with 22q11.2DS or other GNDs and cross-GND studies that may aid in our understanding of the (shared) underlying mechanisms and move treatment discoveries.In chapter 9 the impact of the included studies in this thesis is discussed on society, including health care, and science. Mostly, impact was achieved by implementation of study results and recommendations described in this thesis into the clinical recommendations for children and adults with 22q11.2DS, and by sharing results with a broad audience of physicians of various medical specialties and adults with 22q11.2DS and their families in order to improve care and quality of life of adults with 22q11.2DS.