Page 129 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax

Recovery of microvascular dysfunction following STEMI
Limitations
Several limitations should be mentioned. First, intracoronary measurements were performed within one week following STEMI and the CFR may have partly recovered. Subsequently, the association between CFR in the subacute phase and LVF may have been underestimated. Second, a CFR value of 2.0 was arbitrarily chosen because of the median values of CFR in the present study.
Conclusions
Microvascular dysfunction in the subacute phase, as measured by CFR, is associated with LVF at two years in STEMI. Improvement of CFR and a decrease in HMRI within the initial months following STEMI is associated with early LVEF improvement in patients with a large infarct size, underlining the functional significance of the microvasculature after STEMI.
Impact on daily practice
The results of the current study support the growing evidence on the role of the 7 microvasculature status following STEMI and its effect on LVF. We demonstrated
that microvascular dysfunction, as measured by CFR, is associated with LV improvement in the long term. This underlines the importance of possible therapeutic strategies aimed at restoring or protecting the microvasculature
following STEMI.
Conflict of interest statement
The authors have no conflicts of interest to declare.
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