Page 100 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax

Chapter 6
Methods
Study Population
Between April 1997 and September 2006, we evaluated patients with stable CAD whose diagnostic angiography showed ≥1 intermediate coronary artery lesion at visual assessment. These patients were enrolled in a series of study protocols,6–9 and patient and procedural characteristics were entered into a dedicated database. We excluded patients with ostial lesions, ≥2 stenoses in the same coronary artery, severe renal function impairment (glomerular filtration rate calculated according to the Modification of Diet in Renal Disease formula <30 mL/min per 1.73 m2), significant left main coronary artery stenosis, atrial fibrillation, recent myocardial infarction (<6 weeks before screening), prior coronary artery bypass graft surgery, or visible collateral development to the perfusion territory of interest. The institutional ethics committee approved the study procedures, and all patients gave written informed consent.
Cardiac Catheterization Procedure
Coronary angiography was performed according to standard clinical practice, and angiographic images were obtained in a manner suitable for quantitative coronary angiography analysis. Quantitative coronary angiography analysis was performed offline to determine percent diameter stenosis with the use of a validated automated contour detection algorithm (QCA-CMS version 3.32; MEDIS, Leiden, The Netherlands).
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