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However, the implementation of the ASAS/OMERACT core-sets has so far not been evaluated. The main purpose of this systematic literature review, therefore, is to analyze and compare the usage of domains and instruments of the core-sets before and after the publication of the original article (April 1999). In addition, we checked the implementation of ASAS response criteria.
METHODS
In order to ensure the transparent and complete reporting of this systematic review, the PRISMA statement was used as guidance 6. The research question was structured according the PICOT strategy: population, interventions, control group, outcome and study types. The ‘population’ was defined as trials in patients with a diagnosis of AS or SpA. The ‘intervention group’ was defined as trials with pharmacological and non-pharmacological interventions published after April 2001 (the date was defined two years after the publication date to ensure that there was sufficient time to include the core set measures in RCTs). The ‘control group’ was defined as trials with pharmacological and non-pharmacological interventions published before April 2001. ‘Outcome’ was defined as the domains and instruments in the core-sets for SMARD/physical therapy and DC- ART. ‘Study type’ was confined to RCTs.
A systematic literature search was performed in PUBMED Medline and EMBASE electronic library databases to identify target studies using a comprehensive search strategy. The search was updated last on 18 June 2013, without limitation of years of publication.
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