Page 43 - Helicobacter pylori and Gastric Cancer: From Tumor microenvironment to Immunotherapy

Table 1: Small molecules related Hedgehog expression in Gastric Cancer.
S/N
Homologs
Normal stomach
Stomach Metaplasia
Tumour Intestinal Diffuse
Techniques
Ref
1
Shh
Gland Epithelium
Undetectable
elevated
Undetectable
IHC,RT-PCR IHC, RT-PCR RT-PCR,IHC,IMF
(65) (66) (67) (68)
2
Ihh
Pit Epithelium
Undetectable
elevated
Undetectable
IHC, RT-PCR PCR,IHC,IMF
(65) (55)
3
Dhh
Gland Epithelium
Undetectable
elevated
elevated
IHC, RT-PCR PCR,IHC,IMF
(65) (55)
4
Ptch1
Pit Mesenchyme
Detected
elevated
elevated
IHC, RT-PCR
RT-PCR, IMF RT-PCR, LacZR
(65) (55) (8)
5
SMO
Pit / Gland Mesenchyme
Detected
elevated
elevated
IHC, RT-PCR PCR,IHC,IMF
(65) (55)
6
Gli 1
Pit / Gland Mesenchyme
Undetectable
elevated
elevated
IHC, RT-PCR PCR,IHC,IMF
(65) (55)
7
Gli 2
Pit Mesenchyme
Undetectable
elevated
elevated
IHC, RT-PCR PCR,IMF
(65) (55)
8
Hip
Detected
Not Reported
Undetectable
Not Reported
RT-PCR, IMF
(55, 65)
9
BOC
Pit
Undetectable
elevated
elevated
IHC, RT-PCR
(65)
NOTE: NA: not available; Hh: Hedgehog; Gli: glioma-associated oncogene; Pitch: Patched; Smo: Smoothened; Shh: Sonic Hh; IHC = immunohistochemistry, ISH= in situ hybridization, LacZ reporter. RT-PCR real-time PCR.
Gastric cancer and the Hedgehog Signalling
Gastric cancer and Hedgehog signalling
37
41
2