Page 175 - Helicobacter pylori and Gastric Cancer: From Tumor microenvironment to Immunotherapy

atrophy and should function as a useful assessment tool for evaluation of premetastatic tumor conditions during an endoscopic investigation in routine clinical practice, particularly for patients in developing countries.
Future Perspectives
Hence the former, it seems expedient to restrict the experimental use of Hedgehog inhibitors to those gastric cancer patients that show exaggerated Hedgehog signaling. This is of relevance because currently multiple trials using Vismodegib for the treatment of gastric cancer are being conducted. Although as yet unpublished results indicate that using Hedgehog inhibitors for gastric cancer in unselected patients is not useful, whereas using Vismodegib in selected patients seems to yield better results. And thus, the use of Vismodegib for gastric cancer can serve as a powerful example of the necessity to further develop precision medicine.
Accumulating preclinical as well as clinical studies has shown that the efficacy of checkpoint inhibition could be amplified through dual blockade or in combination with other immunotherapies such as cancer vaccines or adoptive cell therapy. As such, it is worth combining various immune reagents to achieve a maximal effect. Moreover, it is possible that further applications of this approach to traditional chemotherapy or radiation therapy could produce better clinical responses in patients with gastric cancer.
Future studies should clarify the extent to which this novel signaling cascade is involved in other Sonic Hedgehog functions during development. For future research, we recommend an inter-observer agreement done in routine clinical practice among H. pylori-associated gastritis. Parietal cell antibodies should be measured in patients with autoimmune gastritis. Thus in conjunction I feel my thesis opens many novel avenues for future research aimed at better prevention and treatment of gastric cancer. In Conclusion, I feel my thesis opens many novel avenues for future research aimed at better prevention and treatment of gastric cancer.
Summary
Summary
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