Page 40 - Physical activity in recipients of solid organ transplantation - Edwin J. van Adrichem

Chapter 3
Abstract
Background
Objective
Design
Methods
Results
Exercise capacity, muscle function, and physical activity levels remain reduced in recipients
of lung transplantation. Factors associated with this de

e study aims were to analyze the longitudinal change in 6-minute walking distance and

ciency in functional exercise
capacity have not been studied longitudinally.
to identify factors contributing to this change.

is was a longitudinal historical cohort study.
Data from patients who received a lung transplantation between March 2003 and March
2013 were analyzed for the change in 6-minute walking distance and contributing factors
at screening, discharge, and 6 and 12 months after transplantation. Linear mixed-model
and logistic regression analyses were performed with data on characteristics of patients,
diagnosis, waiting list time, length of hospital stay, rejection, lung function, and peripheral
muscle strength.
Data from 108 recipients were included. Factors predicting 6-minute walking distance
were measurement moment, diagnosis, sex, quadriceps muscle and grip strength, forced
expiratory volume in 1 second (percentage of predicted), and length of hospital stay. After
transplantation, 6-minute walking distance increased considerably.

is initial increase was
not continued between 6 and 12 months. At 12 months after lung transplantation, 58.3%
of recipients did not reach the cuto

point of 82% of the predicted 6-minute walking
distance. Logistic regression demonstrated that discharge values for forced expiratory
volume in 1 second and quadriceps or grip strength were predictive for reaching this
criterion.
Limitations
missing data points.
Study limitations included lack of knowledge on the course of disease during the waiting
list period, type and frequency of physical therapy after transplantation, and number of
38.