Page 130 - Physical activity in recipients of solid organ transplantation - Edwin J. van Adrichem

Chapter 7
Abstract
Background
Methods
and once following return.
Results
It is generally unknown to what extent organ transplant recipients can be physically
challenged. During an expedition to Mount Kilimanjaro, the tolerance for strenuous
physical activity and high-altitude of organ transplant recipients after various types of
transplantation was compared to non-transplanted controls.
Twelve organ transplant recipients were selected to participate (2 heart-, 2 lung-, 2 kidney-,
4 liver-, 1 allogeneic stem cell- and 1 small bowel-transplantation). Controls comprised the
members of the medical team and accompanying family members (n = 14). During the
climb, cardiopulmonary parameters and symptoms of acute mountain sickness were
recorded twice daily. Capillary blood analyses were performed three times during the climb
Eleven of the transplant participants and all controls began the

nal ascent from 4700
meters and reached over 5000 meters. Eight transplant participants (73%) and thirteen
controls (93%) reached the summit (5895m). Cardiopulmonary parameters and altitude
sickness scores demonstrated no di

erences between transplant participants and controls.
Signs of hyperventilation were more pronounced in transplant participants and adaptation
to high-altitude was less e
resulted in reduced metabolic compensation.
Conclusion

ective, which was related to a decreased renal function.

is
Overall, tolerance to strenuous physical activity and feasibility of a high-altitude expedition
in carefully selected organ transplant recipients is comparable to non-transplanted controls.
128.