Page 98 - The role of advanced echocardiography in patients with ischemic heart disease - Rachid Abou

Chapter five. Layer-specific LV GLS and remodeling
Table 2. Baseline characteristics of the study population
Variables
Total population (n=502)
No adverse remodeling (n=321)
Adverse remodeling (n=181)
p-value
Aspirin, n (%)
Thienopyridines, n (%) ACEi/ARBs, n (%)
β-blockers, n (%)
Statins, n (%)
Aldosterone antagonists, n (%) ICD (within 6-months), n (%)
484 (97) 501 (100) 489 (97) 479 (95) 500 (100) 7 (1) 14 (3)
309 (96) 321 (100) 312 (97) 306 (95) 319 (99) 5 (2)
8 (3)
175 (97) 180 (99) 177 (98) 173 (96) 181 (100) 2 (1)
6 (3)
0.569 0.183 0.688 0.896 0.287 0.687 0.591
Data are presented as mean ± standard deviation, number (percentage) or as median (25th-75th percentile). ACE = angiotensin converting enzyme; ARB = angiotensin receptor blocker; ICD= implantable cardioverter defibrillator. p-values are presented for the comparisons between different groups.
Table 3. Baseline echocardiographic findings of the study population
Variable
Total population (n=502)
No adverse remodeling (n=321)
Adverse remodeling (n=181)
p-value
LV mass, indexed (g/m2)
LV end-diastolic volume (ml) LV end-systolic volume (ml)
LV ejection fraction (%)
LV end-diastolic diameter (mm) LV end-systolic diameter (mm) Wall motion score index
Mitral regurgitation ≥ 2, n (%) E-prime (cm/s)
E/A ratio
Deceleration time (ms)
Full wall LV GLS (%)
LV GLS at endocardium (%)
LV GLS at mid-myocardium (%) LV GLS at epicardium (%)
111 ± 30 103 ± 34 56 ± 21 46 ± 9 48 ± 6 33 ± 7 1.5 ± 0.3 30 (6) 5.5 ± 1.6
0.9 (0.7-1.1) 210 ± 74 -13.3 ± 3.9 -15.6 ± 4.1 -13.6 ± 3.5 -11.6 ± 3.0
111 ± 32 111 ± 34 59 ± 22 47 ± 8 48 ± 6 33 ± 6 1.5 ± 0.3 23 (7) 5.6 ± 1.6 0.9 (0.8-1.1) 213 ± 72 -14.2 ± 3.6 -16.6 ± 3.7 -14.5 ± 3.2 -12.4 ± 2.8
112 ± 27 88 ± 30 49 ± 20 45 ± 9 48 ± 7 34 ± 7 1.5 ± 0.3 7 (4)
5.4 ± 1.6 0.9 (0.7-1.1) 206 ± 78 -11.7 ± 4.0 -13.9 ± 4.4 -12.0 ± 3.5 -10.0 ± 2.8
0.692 <0.001 <0.001 0.008 0.792 0.501 0.166 0.134 0.194 0.020 0.332 <0.001 <0.001 <0.001 <0.001
Data are presented as mean ± standard deviation, number (percentage) or as median (25th-75th percentile). GLS= global longitudinal strain; LV = left ventricular. p-values are presented for the comparisons between different groups.
In terms of baseline echocardiographic data, patients who showed adverse LV remodeling had significantly smaller LV volumes and lower LVEF at baseline when compared to patients without adverse LV remodeling (Table 3). However, no differences for WMSI and frequency of significant MR were observed between the two groups.
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