Page 81 - The role of advanced echocardiography in patients with ischemic heart disease - Rachid Abou

(≥50%) at 6 months follow-up. CRT was introduced as interaction term of time of implantation (median 9 days, interquartile range 7-28 days). On univariable analysis, peak troponin T levels, baseline LVEF and significant mitral regurgitation were significantly correlated with LVEF recovery. On multivariable analysis, lower peak troponin T levels (odds ratio [OR]: 0.895; p <0.001), baseline LVEF (OR 1.069; p =0.023) and absence of significant mitral regurgitation (OR 0.376; p =0.018) were independently associated with normalization of LVEF (≥50%) at 6 months follow-up, whereas guideline-based medications were not (Table 3).
Table 3. Uni- and multivariable analyses to investigate independent correlates of left ventricular 4 function recovery at 6 months’ follow-up.
Univariable analysis
Multivariable analysis
Variable
Odds ratio
95% CI
p-value
Odds ratio
95% CI
p-value
Age, years
Gender, (male)
ACEi/ARBs, at discharge
β -blockers, at discharge
Statins, at discharge
Aldosterone antagonists
Cardiac resynchronization therapy*
LAD as culprit vessel
Three-vessel disease
Peak troponin T level
Heart rate, at discharge
LVEF (%), at baseline
Significant mitral regurgitationⱡ, at baseline
1.005 0.916 1.937 1.302 0.962 0.957 -----
0.403 0.957 0.872 0.992 1.103 0.246
0.988-1.023 0.550
0.566-1.485 0.723 0.200-18.808 0.569 0.512-3.07 0.579
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
0.995 0.990-1.001
0.668 0.413-1.080 ----- -----
0.895 0.854-0.939 ----- -----
1.069 1.009-1.133 0.376 0.168-0.844
----- ----- ----- ----- ----- ----- 0.106
0.100 ----- <0.001 ----- 0.023 0.018
0.159-5.828 0.386-2.369 -----
0.260-0.623 0.577-1.588 0.834-0.913 0.976-1.009 1.049-1.160 0.117-0.519
0.966 0.942 -----
<0.001 0.865 <0.001 0.346 <0.001 <0.001
ACEi = angiotensin converting enzyme inhibitor; ARB = angiotensin II receptor blocker;
anterior descending coronary artery; LV = left ventricular; LVEF= left ventricular ejection fraction. * = interaction for STEMI date and date of cardiac resynchronization therapy implantation. ⱡSignificant mitral regurgitation was defined as moderate or severe mitral regurgitation
LAD = left
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