Page 162 - The role of advanced echocardiography in patients with ischemic heart disease - Rachid Abou

Chapter eight. LV mechanical dispersion versus LV scar burden
Figure 5. Receiver operating characteristics curves for combined endpoint . This figure demonstrates receiver operating characteristics curves for several echocardiographic parameters and parameters derived from cardiac magnetic resonance.
DISCUSSION
The present study showed that LV MD is significantly related with total scar burden, infarct core and border zone in STEMI patients. In addition, patients with prolonged LV MD showed higher event rates. Finally, prolonged LV MD provided the highest predictive value for the combined endpoint when compared to other echocardiographic and LGE-CMR derived parameters.
Association between left ventricular mechanical dispersion and scar burden
LGE-CMR has been proven to accurately quantify the extent of LV myocardial scar and is a powerful prognostic parameter in patients with ischemic heart disease.17,18 It has been suggested that the anatomical substrate for ventricular arrhythmias post- myocardial infarction is predominantly determined by the scar heterogeneity, which provides a substrate for a re-entry circuit.19
A recent meta-analysis including 1105 patients demonstrated that the occurrence of ventricular arrhythmias were predominantly observed in patients with a greater extent
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