Page 31 - 2015-09-01 AMC Steeneke.pptx
P. 31

grafische uiting:
General introduction
n op een
Word
ompo
s
enal,
4
-
h
y
graphic
food-
b
o
r
n
e
α
s
tiar se
is
th
a
n
th
erl
a
nd
pr
e
an
cy
h
il
db
irt
nd
o
stn
at
al
p
er
d
e
h
y
i
t
co
n
ta
ls
(t
e
rtiar
yc
ar
e
)[
10].
Exposure to α,β-unsaturated aldehydes also comes from other sources than the diet.
Alicyclic
d
ro
x
y
-
2
-
a
l
k
e
n
a
gu
basesecondary care are defined in the List of Obstetric Indications (Verloskundige
id
e
th
e
risk
se
l
ec
tio
n,
t
he
in
di
ca
tio
n
s
for
re
fe
rr
al
to
a
nd
cons
u
lt
at
io
n
of
Descriptionofthecategory Alphatic
Name
Structure
Sources
red wine [1], tabacco smoke [2]
red wine [1], tabacco smoke [2]
banana [1], fig [17]
grape, orange [1]
cucumber [18]
black tea [19]
d on the structural similarity [14]
r
b
a
l
d
e
h
y
Cinnamyl derivatives and other aromatic alkyl substituted aldehydes
Heterocyclic
Others
cassia(bark
oil) [1]
I
ndic
at
ie L
ij
st)
–
a
l
is
tb
as
e
d
o
n
sci
en
t
ific
e
v
ide
n
c
e
an
d
co
ns
ensus among the
ca 2-
de in)
l
t
s
essence perceived as being ‘physiological’. By supervising low risk pregnancies, births and postnatal periods in primary maternity care, and only cases of (expected) complications/pathology in secondary maternity care, the various maternity care professionals’ expertise can be applied to its full potential [11]. To
products including 2-propenal, 4-hydroxy-2-alkenals, and malondialdehyde [16].
β
various maternity care professionals. Currently the third revision of this list, published in 2003, is in use.
2,6,6-trimethylcycloh
Table 1.1 Examples of food-borne α,β-unsaturated aldehydes listed in accordance with the
,
-
u
n
at
u
r
a
e
d
a
l
d
e
h
y
This thesis is specifically focusing on primary maternity care, with the abovementioned primary care midwives as the main care providers. Approximately 77% of the 2444 midwives in the Netherlands provide this type of
de)
x
2-propenal (acrolein)
tabacco smoke
trans-2-hexenal trans-2-octenal
trans-2-cis-6-nonadie nal 2-methylcrotonaldehy
cacao, cofofestee,r an environment that offers help and support for physical and mental health meat prodaus cwtsell as social and cultural issues that can affect health and wellbeing.
care [12]. Between 1999 and 2012, the majority of pregnant women in the Netherlands (83.2%) had their first maternity care check-up in a primary care
y tting. E
c ven
a tuall
r y, 5
e 4.3% o
i ft
s he pre
p gnan
r tw
activities are
Organtirsatinonso-f2M-ihdweivxese(nKNaOlV), the first prenatal visit (intake) should ideally be
1.3
ADME (absorption, distribution, metabolism and excretion)
y
y care,
performed.
According
to the
standards of the Royal Dutch
This introductory chapter provides background information on the organisation of Netherlands (83.2%) had their first maternity care check-up in a primary care
,
a
n
d
m
a
Name Structure
Sources
red wine [1],
population density [9]. Secondary and tertiary care is provided by obstetricians
and specialised ‘clinical’ midwives in general (secondary care) and academic 1 hospitals (tertiary care) [10].
One of the basic pillars of the Dutch maternity care system is risk selection. Risk selection is conducted at primary care level by only referring women and newborns with complications or an increased risk for developing complications to secondary care. Thus these primary maternity care professionals serve as gatekeepers to secondary maternity care. The basic principle behind risk selection is that in the Netherlands, pregnancy, childbirth and the postnatal period are in essence perceived as being ‘physiological’. By supervising low risk pregnancies, births and postnatal periods in primary maternity care, and only cases of (expected) complications/pathology in secondary maternity care, the various maternity care professionals’ expertise can be applied to its full potential [11]. To guide the risk selection, the indications for referral to and consultation of secondary care are defined in the List of Obstetric Indications (Verloskundige IndicatieLijst)–alistbasedonscientificevidenceandconsensusamongthe various maternity care professionals. Currently the third revision of this list, published in 2003, is in use.
α,β-Unsaturated aldehydes are rapidly absorbed, distributed, metabolized and excreted in urine,
o om
v en s
i ta
d rted
l
o
n
d
i
Opmaak en vormgeving van uw proefschrift
Vanuit PDF
n mechanism, yields lipid hydroperoxides as major initial reaction
2-Propenal (acrolein) and 2-butenal (crotonaldehyde) for example are produced during α,β-unsaturation in p-mentha-1,8-dien-7-
α,β-unsaturation in side chain
α,β-unsaturation in ring/side chain
more complex
Cinnamyl aldehyde
2-phenyl-2-alkenals cassia
p-mentha-1,8(10)-die n-9-al
p-mentha-1,8-dien-7- al
2,6,6-trimethylcycloh exa-1,3-diene-1- carbaldehyde
trans-cinnamaldehyd e
1
One of the basic pillars of the Dutch maternity care system is risk selection. Risk
combustion of organic materials and therefore found in all types of smoke including cigarette
selection is conducted at primary care level by only referring women and
smoke and exhaust from engines [2, 10]. 2-Propenal is present at 25 – 140 μg/cigarette in the gas ring/side chain al
newborns with complications or an increased risk for developing complications to
a number of degradation de [16].
Paginarand
i
o
n
o
f
l
i
p
i
d
h
y
d ti
a
ry
ca the
re. Ne
Th
u
s
t
h s,
ese
p gn
rim
ar
d
r
o
p
e
r
o
x
i
d
se
gatekeepers to secondary maternity care. The basic principle behind risk selection
y ,c
m
at
er
n
ity ha
c
a
re the
p p
e
s
g
rofe
ss
io
na
ls
s io
e labo
d
es
l
i
s
e
n
e
r
a
d ur in pr
obstetric[2i]ans
and 34.2% gave birth in a primary care setting [13]. red wine [1],
Furfural derivatives
Furans with conjugationinside chain
Other sulphur containing substances
[21]
Furthermore, it offers new parents support for parenting and the responsibilities that come with it [2]. Despite these advantages and the universal accessibility of prenatal and postnatal care, previous studies in the Netherlands have demonstrated that non-western women from various ethnic origins are more likely to make inadequate use of these services [3-7].
Research conducted so far, has not been able to give a complete understanding of non-western women’s prenatal and postnatal care utilisation in the Netherlands. Filling this gap in knowledge and understanding provided the main rationale for conducting this study. The second rationale was gaining insight into the interactions between non-western women and the maternity care professionals involved, as this may affect the utilisation of prenatal and postnatal care.
Paginaran
Prima2ry-bmuidwteifneraylcareincludescareprovidedduringpregnancy(prenatalcare),
neral (secondary care) and academic
1
General Introduction
2-alkylated aldehydes withorwithout de
childbirth (natal care) and after birth (postnatal/postpartum care). Prena(tcalrocatreonenacolmdpeahssyesdseup)ervision of pregnant women from pregnancy confirmation during the prenatal period until birth. It consists of an intake and several follow-up visits in which diagnostic, counseling and health education
2-phenyl-2-alke
n
ls
a
l
d
b imar
er
v ar
t
PDF design
•  Basic; toevoeging 1 grafisch element, omzetten naar drukbestand
PDF opmaak basic € 75,-
•  Standaard: toevoeging 3 grafisch elementen, omzetten naar drukbestand
Vanuit PDF
Vanuit Word doc
f koptekst, òf paginacijfers, òf zijkant blokje
Pagina afloop
-unsaturated aldehydes also comes from other sources than the diet. Alicyclic
Binnen werk
α,β-unsaturation in p-mentha-1,8(10)-die side chain n-9-al
Meerdere grafische uitingen tegen meerprijs
nd 2-butenal (crotonaldehyde) for example are produced during
1
aterials and therefore found in all types of smoke including cigarette engines [2, 10]. 2-Propenal is present at 25 – 140 μg/cigarette in the gas
t €400,-
General introduction
PDF opmaak basic
1 grafische uiting:
òf koptekst, òf paginacijfers, òf zijka Meerdere grafische uitingen tegen
β-Un
s
t
m
ed endogenously by lipid
urate
p
op
u
la
tio
n
d
e
ns
ity [
9]
.
Se
co
nd
ar
y
an
dt
er
tia
ry
ca
re
i
s
pr
ov
id
ed
by
o
bst
o
r
a
t
u
r
a
t
e
d
a
l
d
e
h
y
d
e
s
a
r
e
f
and specialised ‘clinical’ midwives in general (secondary care) and academic
1
h
ospi
a
t
t
y
a
c
i
d
s
(PUFAs) [2, 15]. Lipid peroxidation, initiated by a
d
f
u
r
h
e
r
m
o
r
e
f
e
tric
ia
ns
t
e
s
phase of the smoke [2]. α,β-Unsaturated aldehydes are furthermore formed endogenously by lipid
e
as
peroxidation of polyunsaturated fatty acids (PUFAs) [2, 15]. Lipid peroxidation, initiated by a free-radical chain reaction mechanism, yields lipid hydroperoxides as major initial reaction products. Subsequent decomposition of lipid hydroperoxides generates a number of degradation
e
d
in accordance with the
more comcaptegloerixes made by EFSA basedxonath-e1st,ru3ct-udraliseimnileari-ty1[1-4]
ei
n
y
y care,
tabacco smoke
Zwarte balk t.b.v. trapeffect
[2]
x-2-enal
citral (mixture of neral and geranial)
trans-2-trans-4-hexad
This thesis is specifically focusing on primary maternity care, with the abovementioned primary care midwives as the main care providers. Approximately 77% of the 2444 midwives in the Netherlands provide this type of care [12]. Between 1999 and 2012, the majority of pregnant women in the
Cinnamyl
derivatives
and other
aromatic alkyl
substituted
Two or more
2-butenal
pregnant
women
is not only
important
during
aldehydes
additional double
trans-2-methyl-2-pete
to16prenatalvisitsshouldideallybemade,withanaverageof13,dependingon Heterocyclic faecesandexpiredacir.aWchaenom,alceoWfisftaerera,tswereexpo
non-western women in the Netherlands. In addition, information is given about
necessary medical care and the needs and expectations of clients. In the first grape, orange
trans-2-octenal Skilled professional care for pregnFaurnfutralwdeormivaet
[1]
kg
bw
of
rnity care system is risk selection. Risk
double-bonds with or
trans-2-trans-4-octad rt
h
o
s
p
i
t
a
l
s
(
t
e
r
t
i
a
r
y
c
a
r
e
)
[
1
0
]
.
Prenatal care encompasses supervision of pregnant women from pregnancy cseovnefirraml aftoiollonwd-urpingvistihtse pinrewnahtiachl pdeiraiogndousntitci,l bcoiruthn.seItlincgonasnisdts hoefaaltnh inetdaukceataionnd
level by only referring women cuacunmbder [18] Furans with
primary, secondary and tertiary care [8]. Primary care is provided by primary care
Chapter 1 9 trans-2-cis-6-nonadie
midwives, autonomous qualified medical professionals providing full maternity mg/kg bw 14C labelled 2-propenal by gavage [23]. Urine was the major excretion rocuatre on their own accountability, and a small number of general practitioners active in midwifery care. Latter are mainly engaged in rural areas with a low
nal
period, professional care is generally acknowledged to be effective in preventing
One of the basic pillars of the Dutch maternity care system is risk selection. Risk 811 Non-western women in maternity care in the Netherlands Chapter 1 9
selection is conducted at primary care level by only referring women and
he
aternity care professionals serve as
hydes
conjugation in side Furfurylidene-2-buta
Bo
d
e
s
y
10
erle
i
der
.ind
d9
21-02
-15 18
:47
d
ri2s-mkethfyolcrotodnaeldevhyeloping com de
p
l
ications to
adverse pregnancy outcomes, and it is considered to bnealeffective in detecting and chain
e trans-2-methyl-2-pete
lifestyle and facilitating informed choice [1]. In the postnatal period professional
nal
containing substances -3-phenylpropenal
sic
pri
dr
isk
sel
daard €175,-
.
PThDF opmaak stan
e ba
ncip
le be
hin
care is necessary to maintain and promote the health of mother and child, to
ec
tio
n
Cinnamyl aldeh
y
furoalnly important during childbirth, but also during the prenatal and postnatal period. In the prenatal
treating complications, providing timely interventions, promoting a healthy
newborns with complications or an increa
e
d
risk for developing com
p
l
ications to
Others
black tea [19] Other sulphur 2-(Methylthiomethyl)
32620 Reiko Kiwamoto.indd
11
17-03-15 15:34
foster an environment that offers help and support for physical and mental health
PDF opmaak stan
dbirtcihtral a(mnixtdure tofhe postnatal period are in as well as social and cultural issues that can affect health and wellbeing.
essence perceived as being ‘physiologic
al’.
By
supe
rv
isin
g low
ri
sk
preg
na
n
cie
s,
lime [1] 1.3
ADME (absorption, distribution, metabolism and excretion)
By
matrtaens-r2n-traitnsy-4-hecxad re, and only casefsig [1o7],f α,β-Unsaturated aldehydes are rapidly absorbed, distributed, metabolized and excreted in urine,
ith or
supe
rv
isin
g low
sk
preg
na
n
cie
s,
ri
trans-2-nonenal or trans-2-pentenal by gavage [22], both aldehydes entered the systemic be applied to its full potential [11]. To likely to make inadequate use of these services [3-7].
neral and geranial)
Furthermore, it offers new par
en
ts s
up
p
ort for parenting and the responsibilities
births and postnatal periods in primary maternity care, and only cases of
that come with it [2]. Despite these advantages and the universal accessibility of
(expected) complications/pathology in 3segcroanfidasrcyhmeautietrinnitgyecna:re, the various
prenatal and postnatal care,
previous studies in the Netherlands have
maternity care professionals’ expertise can be applied to its full potential [11]. To
ienal blueberry [20] faeces and expired air. When male Wistar rats were exposed to 100 mg/kg bw of 14C labelled egcroanfidasrcyhmeautietrinnitgyecna:re, the various demonstrated that non-western women from various ethnic origins are more
• paginacijfers
secondary care are defined in the List of Obstetric Indications (Verloskundige
al trans-2-trans-4-octad koptekst
With or without additional
5-methyl-2-phenylhe
d double-bonds
no
n-
co
njugated e
-2 oil) [1]
-e
a
with or without additional double-bonds
-b
3-alkylated aldehydes
on
ds
nal
tr
(
a
e
n
s
p
rop
en
-
a
l (a
cro
le
General Introduction
c
i
n
namaldehyd
replaced graphic
5-methyl-2-phenylhe
(
cro
to
na
ld
eh
y
lime [1]
made between the 6th and 8th week of pregnancy [14]. Throughout pregnancy 10 [17] zijkant boek among non-western women and the utilisation of prenatal and postnatal care by and 34.2% gave birth in a primary care setting [13]. 1
banana [1], fig
nd tertiar se
c ven
conjugated ienal blueberry [20]
14
C
l
ab
n
i
s
nFou ien al
without additional
circulation from the mgasteroaintesptinraol (dGIu) tcratcst, and were
acids within 24 hours. Only trace amount of trans-2-nonenal or trans-2-pentenal were foundIninthe Netherlands, maternity care is organised in a model consisting of so called
i
v
e
s
met
o double-bonds
cg
n
n
-c
on
jug
a
ted
anis
ati
fig [17],
a
l
b
a
rk nal
Furfural
Furfurylidene-2-buta nal
2-(Methylthiomethyl) -3-phenylpropenal
n
trans-2-nonenal or trans-2-pentenal by gavage [22], both aldehydes entered the systeminitchis thesis.
faeces [22]. In anoth[er2st1ud]y, male and female Sprague-Dawley rats were exposed to 2.5 or 15
activities are performed. According to the standards of the Royal Dutch Organisation of Midwives (KNOV), the first prenatal visit (intake) should ideally be made between the 6th and 8th week of pregnancy [14]. Throughout pregnancy 10 to 16 prenatal visits should ideally be made, with an average of 13, depending on necessary medical care and the needs and expectations of clients. In the first
population de ma
n terni
sed
to
100 m
g/
el
led
abo
liz
d
s
p
e
c
ia
i
s
e
d ‘clinical’ midwives in general (secondary care) and academic childbirth (natal care) and after birth (postnatal/postpartum care).
ed
to
y
iel
d
C-3
m
e
rca
pt
uOrir
Skilled professional care for
childbirth, but also during the prenatal and postnatal period. In the prenatal period, professional care is generally acknowledged to be effective in preventing adverse pregnancy outcomes, and it is considered to be effective in detecting and treating complications, providing timely interventions, promoting a healthy lifestyle and facilitating informed choice [1]. In the postnatal period professional care is necessary to maintain and promote the health of mother and child, to
obstetricians the aim, research questions and theoretical framework of the research presented Primary midwifery care includes care provided during pregnancy (prenatal care),
s ty c
i a
t re,
on of
ma
y the no
ter
nit
[ n-
9 wes
y ca
] ter
.
n pop
re in
th
eN
ethe
rl
ands
S ula
e tion
c , pe
o rina
n tal a
d nd m
a ate
r rna
y
l mort
a ality
y tting. E
a tuall
s
secondary care. Thus these primary maternity care professionals serve as
gatekeepers to secondary maternity care. The basic principle behind risk selection is that in the Netherlands, pregnancy, childbirth and the postnatal period are in
• koptekst
guide the risk selection, the indications for referral to and consultation of
3
2429
Boerlei
der.indd 9
21-02
-15 18
:47
r y, 5
e 4.3% o
i ft
s he pre
p gnan
r tw
o om
v en s
i ta
d rted
e labo
d ur in pr
b imar
da


































































































   29   30   31   32   33