Page 54 - Go4it
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Chapter 4
Table 1: Baseline characteristics of intervention (Go4it) and control group.
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Sex, n
Male / Female
Age, years
Weight, kg
Weight sds
Height, cm
Height sds
Body Mass Index, kg/m2
Body Mass Index sds
Degree of overweight, n Overweight
Obese
Ethnicity, n Western Non-western
Prediabetes
Impaired Fasting Glucose Impaired Glucose Tolerance
Tanner stage, nb Pre-pubertal (stage 1) Pubertal (stage ≥ 2)
Intervention group (n=71)
33 / 38 14.5 (1.7)a 94.7 (18.4) 3.03 (0.81) 167.9 (9.6) 0.17 (1.1) 33.3 (4.6) 2.93 (0.41)
5 66
36 35
6 4
25 40
Control group (n=51)
21 / 30 14.4 (1.8) 92.2 (18.5) 2.96 (0.88) 165.0 (8.2) -0.05 (0.93) 33.6 (5.1) 2.93 (0.51)
7 44
18 33
3 2
16 34
p-value 0.56d
0.73c 0.47c 0.65c 0.08c 0.24c 0.73c 0.99c
0.22 d
0.09 d
0.60d 0.63d
0.47d
a Values are means (SD), b For Tanner stage missing values were 6 for intervention and 1 for the control group; c t-test, d Chi-Square test
Table 2 shows the change in anthropometrics and body composition as well as metabolic components. The primary outcome BMIsds was significantly reduced in the Go4it group at 18 months follow-up (between group difference: -0.16; 95% CI: -0.30; -0.02). Concretely, in the intervention group (n=36) BMIsds decreased from 2.96 at baseline to 2.86 at 18 months follow-up, while in the control group (n=32) BMIsds increased from 2.91 to 2.96. None of the other body composition or metabolic components showed significant treatment effects. However, according to prediabetes, there were 2 subjects less in the intervention group while in the control group 2 more subject were considered pre-diabetic after 18 months follow-up. In addition, the subjects with lower BMIsds were related to the subjects with lower HOMA-IR at 18 months versus baseline (p=0.054). The treatment effect on BMIsds was moderated by ethnicity at 6 months (p=0.029) and 18 months (p=0.057).
Table 3 shows the results stratified by ethnicity. The treatment effect was significant in adolescents from western descent (-0.35; 95% CI: -0.64; -0.07) but not in those from non-western descent (0.004; 95% CI: -0.14; 0.15). Significant treatment effects were also observed for systolic and diastolic blood pressure, as well as HDL cholesterol level, but only for obese adolescents from western descent.
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