Page 63 - ADULT-ONSET ASTHMA PREDICTORS OF CLINICAL COURSE AND SEVERITY

patients. patients.
BIOMARKERS TO IDENTIFY SPUTUM EOSINOPHILIA IN DIFFERENT ADULT ASTHMA PHENOTYPES
Table E9. Threshold per marker at either 95% sensitivity or specificity in mild-moderate asthma Table E9. Threshold per marker at either 95% sensitivity or specificity in mild-moderate asthma
Test
Test Threshold Sensitivity Specificity
Threshold
Sensitivity Specificity
FeNO FeNO
Blood Eosinophils Blood Eosinophils
Total IgE Total IgE
FeNO+blood eosinophils FeNO+blood eosinophils
≥12.2 ppb
0.96 0.27
≥12.2 ppb ≥63.5 ppb
≥63.5 ppb ≥0.085 x10^9/L
≥0.085 x10^9/L ≥0.34 x10^9/L
≥0.34 x10^9/L ≥13.5 kU/L
≥13.5 kU/L ≥586 kU/L
≥586 kU/L ≥0.138*
≥0.138* ≥0.68*
≥0.68*
0.96 0.27 0.36 0.96
0.36 0.96 0.96 0.25
0.96 0.25 0.39 0.95
0.39 0.95 0.95 0.31
0.95 0.31 0.12 0.95
0.12 0.95 0.96 0.48
0.96 0.48 0.42 0.95
0.42 0.95
Table E10. Threshold per marker at either 95% sensitivity or specificity in severe asthma patients. Table E10. Threshold per marker at either 95% sensitivity or specificity in severe asthma patients.
Test Threshold Sensitivity Specificity
Test FeNO
FeNO
Blood Eosinophils Blood Eosinophils
Total IgE Total IgE
FeNO+blood eosinophils FeNO+blood eosinophils
Threshold Sensitivity Specificity
≥12.4 ppb
0.95 0.30
0.95 0.30 0.38 0.95
0.38 0.95 0.95 0.28
0.95 0.28 0.18 0.95
0.18 0.95 0.97 0.21
0.97 0.21 0.02 0.95
0.02 0.95 0.95 0.37
0.95 0.37 0.46 0.95
≥12.4 ppb ≥65 ppb
≥65 ppb ≥0.085 x10^9/L
≥0.085 x10^9/L ≥0.73 x10^9/L
≥0.73 x10^9/L ≥22 kU/L
≥22 kU/L ≥1815 kU/L
≥1815 kU/L ≥0.095*
≥0.095* ≥0.75*
≥0.75* 0.46 0.95
* Table E3-E10: All test combinations were log transformed; these values correspond to an individual’s probability of s*pTuatbulme Ee3o-sEin10o:pAhlilitae,satscdoemtebrinmaitnieodnsbwy ethre lfogrmtrualnaspforromviedde;dtihneFseigvuareluEe2s.correspond to an individual’s probability of sputum eosinophilia, as determined by the formula provided in Figure E2.
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