Page 162 - Clinical relevance of current materials for cranial implants
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Chapter 8
Background Poly(methyl methacrylate) (PMMA) has been widely used in healthcare for dental prostheses, fixation of hip implants, and skull reconstructions. PMMA is formed through the polymerization of liquid methyl methacrylate (MMA) and PMMA powder. Unreacted MMA (residual monomers) remain in the final product, however, the precise concentrations are not known for all PMMA-based materials.
Objectives The aim of this study is to investigate whether different compositions and fabrication methods of PMMA-based materials differently release residual monomers.
Material and Methods Four representative PMMA-based materials (Vertex Self-Curing, Palacos R+G, NextDent C&B MFH, and DePuy CMW-3) with different compositions were examined by reversed-phase high-performance liquid chromatography (HPLC). The released residual monomer concentration was measured in water at 37.0 ± 1.0 °C and at time points between one hour and 14 days.
Results The different PMMA-based materials demonstrate concentrations of released residual monomers between 22.8 and 78.8 μg/g after 14 days. NextDent C&B MFH, a poly(dimethacrylate), released a significantly lower residual monomer concentration (22.8 μg/g) after 14 days compared to the other materials.
Conclusion Different compositions of PMMA-based materials show different release patterns and quantities of residual monomers. The novel polymer, NextDent C&B MFH, released the lowest amount of residual monomers.

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