Page 101 - Clinical relevance of current materials for cranial implants
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                                Limitations of this study
This study included only one PMMA cranioplasty for analysis. To have more reliable conclusions, a larger number of fractured PMMA cranioplasties should ideally have been included. In this study tissue formation, behavior, and changes in time have not been taken into consideration. These properties may be important and may influence failure rates in clinical circumstances, as such they should be investigated in future studies.
This ex vivo study shows that a CMW-3 cranioplasty after 15 years in vivo had not resulted in a change in molecular weight or flexural strength. However, the design and the manufacturing of the PMMA cranioplasty seem to be important factors for possible improvements in cranioplasties. By curing PMMA under increased pressure, the porosity is reduced As a result the flexural strength is increased.
In vivo fractured PMMA cranioplasty

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