Page 177 - Cellular Imaging in Regenerative Medicine, Cancer and Osteoarthritis

Summary, Discussion, Concluding remarks
Figure 1 Cellular imaging in A regenerative medicine using iron labelled cells for MRI; B cancer cell imaging for PET or SPECT or therapy using radiolabelled cells; C macrophage imaging during osteoarthritis development using radiolabelled cells for PET or SPECT. Inner ring represents the cell used in research. Second ring shows the label. Third ring displays the labelled cells. Outer ring exhibits the model used with an example of an image obtained with the imaging modality applied.
Concluding remarks
In this thesis we showed different methods to label cells for cellular imaging to determine their role in diagnosis and therapy of various diseases (Fig. 1):
• In vitro cell labelling with iron nanoparticles appeared well feasible.
We executed this method via non-specific targeting of the cells using a transfection agent or via specific targeting with the use of targeted ultrasound bubbles. Our labelling procedures did not harm the cells, but
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