Page 156 - Cellular Imaging in Regenerative Medicine, Cancer and Osteoarthritis
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Chapter 7
Figure 4 Cartilage damage and osteophyte formation after induction of experimental osteoarthritis (OA) by DMM. Thionin staining of a mouse knee 8 weeks after OA induction by destabilization of the medial meniscus (DMM). The femur condyle and tibia plateau are shown in the enlargements. The sham-operated knee had a summed OARSI score of 0 and the knee with DMM had a summed OARSI score of 10.5 (maximum possible score 72). Cartilage damage (at asterisk) and osteophytes (indicated by the arrows) were seen in all DMM knees.
Figure 5 Presence of CD64+ macrophages during development of experimental osteoarthritis after DMM. The continuous line represents the DMM knees. The dotted line represents the sham knees. Each group contains 7-9 knees. Data is presented as mean ± SD, p<0.0001 between different time points.
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